Encyclopedia of Signaling Molecules

ISBN-13: 9783319671987 / Angielski / Twarda / 2017 / 6060 str.

Sangdun Choi

Opis

Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life.Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world's foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alikeDuring past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.

Spis treści

From the contents 14-3-3.- 3-Phosphoinositide-Dependent Kinase 1 (PDK1).- 5-HTT.- 5-Hydroxytryptamine Receptor 2C.- 5-Hydroxytryptamine Receptor 6.- A-Kinase Anchoring Protein (AKAP).- A-RAF.- ABCA Transporters.- ABCA3.- ACAP1.- Acetylcholine (Nicotinic) Receptor.-  Acetylcholinesterase.- ACK1.- ACSL4.- ACT.- Actinin Family.- ADAMTS13.- ADAP.- ADAP1.-  ADAP2.- ADCY9 (Adenylyl Cyclase 9).- Adenomatous Polyposis Coli.- Adenylyl Cyclase.-  ADGRB3.- ADGRG2.- Adiponectin.- ADP-Ribosylation Factor-6 (ARF6).- AGAP1.- AIFM1.-  AIRE.- AKT.- Alpha-1-Syntrophin.- Alpha-2A Adrenergic Receptor.- ALS2.- AMP-Activated Protein Kinase (AMPK).- Androgen Receptor (AR).- ANT.- AP-4.- APO2L/TRAIL.- Apoptosis Regulator BAX.- Apoptosis-inducing factor 1, mitochondrial.- App.- Aquaporin.- ARAP3.- ARF1.-  Arl8b.- Aryl Hydrocarbon Receptor.- Ataxia Telangiectasia and Rad3-Related (ATR).- ATF2.-  ATP-Binding Cassette Subfamily A Member 2.- Aurora Kinases.- Axin.- AXL.- B Lymphocyte Antigen CD19.

O autorze

Sangdun Choi is currently the Chair of the Department of Biological Sciences and a Professor at the Department of Molecular Science and Technology in Ajou University, Korea. He joined the faculty of the Department of Molecular Science and Technology, Ajou University, as an Associate Professor in 2006. His research interests include Toll-like receptor signaling, innate immunity, cellular signaling and systems biology. He earned his PhD at the Texas A&M University, USA. He was one of the pioneers in the development of Bacterial Artificial Chromosomes (BACs). He was instrumental in the construction of a complete human BAC library for the Human Genome Project (HGP). He was also involved in the second consortium, Alliance for Cellular Signaling (AfCS). Furthermore, he served as the Director of the Transcription Analysis Laboratory at the California Institute of Technology (Caltech), USA. He has published more than 200 scientific articles in international journals including Nature, Science, Nature Biotechnology, Blood and Proceedings of the National Academy of Sciences. He has edited seven books including Encyclopedia of Signaling Molecules, Systems Biology for Signaling Networks and Introduction to Systems Biology. He is an academic editor of PLoS ONE and an active editor for several other international journals.

Blurb

The second edition of this encyclopedia presents about 1000 chapters and includes thousands of biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike.

Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research

-based teaching and scientific capabilities.