Enantioselective Organocatalyzed Reactions I: Enantioselective Oxidation, Reduction, Functionalization and Desymmetrization

ISBN-13: 9789401780506 / Angielski / Miękka / 2014 / 322 str.

Be Rainer Mahrwald (Humboldt-University

Opis

Organocatalyzed Reactions I and II presents a timely summary of organocatalysed reactions including: a) Enantioselective C-C bond formation processes e.g. Michael-addition, Mannich-reaction, Hydrocyanation (Strecker-reaction), aldol reaction, allylation, cycloadditions, aza-Diels-Alder reactions, benzoin condensation, Stetter reaction, conjugative Umpolung, asymmetric Friedel-Crafts reactions; b) Asymmetric enantioselective reduction processes e.g. Reductive amination of aldehydes or ketones, asymmetric transfer hydrogenation; c) Asymmetric enantioselective oxidation processes;
d) Asymmetric epoxidation, Bayer-Villiger oxidation; e) Enantioselective a-functionalization; f) A-alkylation of ketones, a-halogenation and a-oxidation of carbonyl compounds.

Recenzje

From the reviews:

"Under Rainer Mahrwald's guidance, the authors have gathered together hundreds of reactions, documented a wide variety of catalysts, and provided clear descriptions and schemes to illustrate the underlying mechanisms. ... all of the chapters are crafted to inspire many new ideas and suggestions for the reader's own work. ... is well worthwhile for large research groups and libraries." (Organic Chemistry Portal, March, 2012)

Spis treści

Organocatalysed Asymmetric Oxidation Reactions (Benjamin R. Buckley, University of Loughborough, UK) - Enantioselective Reductions Using Dihydropyridines (Tommaso Marcelli, Royal Institute of Technology, Stockholm, Sweden) - Organocatalyzed Enantioselective Protonation (Vincent Levacher, INSA-Rouen, France) - Enantioselective α-Heterofunctionalization of Carbonyl Compounds (Diego J. Ramon and Gabriela Guillena, University of Alicante, Spain) - Chiral Primary Amine Catalysis (Sanzhong Luo, Institute of Chemistry, Chinese Academy of Science, China) - Bifunctional Acid-Base Catalysis (Petri Pikho, University of Helsinki, Finland) - Chalcogen-Based Organocatalysis (Ludger Wessjohann, Leibniz Institute of Plant Biochemistry, Halle, Germany)

O autorze

Dr. Rainer Mahrwald

Dr. Rainer Mahrwald was born in 1950. He studied chemistry at MLU Halle and subsequently joined the „Manfred von Ardenne“ Research Institute in Dresden, where he led the synthetics group. He gained his doctorate under G. Wagner in Leipzig in 1979, and went on to the Institute of Organic Chemistry at the Academy of Science in Berlin, where he remained until 1990. Following a stay at the Philipps-University in Marburg, Dr. Mahrwald qualified as a lecturer at the Humboldt University Berlin, where he is now a lecturer.

Blurb

Organocatalysis has emerged as one of the hot topics in organic chemistry in recent years, as confirmed by the rapid-growing interest that researchers have shown in this field.
Enantioselective Organocatalyzed Reaction Volume I and II provides a critical review of the state-of-the-art developments in Organocatalysis, with a special focus on the asymmetric transformation that it enables. These volumes, written by leading experts in the field, discuss a broad range of synthetic transformations and offer an up-to-date coverage of organocatalyzed reactions such as:

• Conjugate addition;
• Aldol addition;
• Oxidation;
• Reduction;
• Cycloaddition;
• Mannich reaction;
• Asymmetric f untionalization;
• Enantioselective  protonation;
• General aspects of asymmetric cyclization;
• Asymmetric desymmetrization processes.

By presenting a complete panorama of the use of organocatalysts in organic reaction, Enantioselective Organocatalyzed Reaction will help the global audience of scientists engaged in this area of research to develop new catalysts as well as new fields of applications in organic synthesis.