Emerging Concepts of Tumor Exosome-Mediated Cell-Cell Communication

ISBN-13: 9781461436966 / Angielski / Twarda / 2012 / 220 str.

Huang-Ge Zhang

Opis

In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.

Spis treści

Preface.- The Cell Biology of Exosomes : Historical and Perspectives.- The role of exosomal shuttle RNA (esRNA) in cell-to-cell.- Exosomal lipids in cell-cell communication.- The Functional Importance Of Tetraspanins In Exosomes.- The effects of exosomes and related vesicles on cancer development, progression, and dissemination.- Circulating Cell-derived Vesicles Mediate Tumor Progression.- Immune modulation of T cells and natural killer cells by tumor-derived exosomes.- The Role Of Tumor Exosomes In Tumorigenicity.- Microenvironmental regulation of metastasis by exosomes.- Microvesicles and their Emerging Role in Cellular Therapies for Organ and Tissue Regeneration.- Index

Blurb

Tumor exsome-mediated cell-cell communication has grown increasingly important in cancer research. Recent findings on vesicle-based information transfer by exosomes have changed our view of the tumor microenvironment.  Currently, exosomes represent the main extracellular processes implicated in the regulation of multiple physiological processes. Importantly, in cancer, exosomes contribute to the formation of the tumor microenvironment, promoting invasion, angiogenesis, immune regulation and metastasis. Therefore, exosomes could be considered one of the major forces acting locally or systemically to promote the continuous crosstalk between the tumor and its microenvironment, influencing the behavior of different cell types such as stromal, endothelial and bone marrow-derived cells.

Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. This volume gives a comprehensive review on current research in this area and also discuss future prospects as prognostic markers for cancer.