Electron Paramagnetic Resonance in Biochemistry and Medicine

ISBN-13: 9781475786897 / Angielski / Miękka / 2013 / 268 str.

Rafik Galimzyanovich Sajfutdinov; Lyudmila Ivanovna Larina; Tamara Il Vakul'skaya

Opis

Electron Paramagnetic Resonance (EPR) spectroscopy - also sometimes termed Electron Spin Resonance spectroscopy - has manifold potential uses in biochemistry and medicine. The paramount importance of EPR spectroscopy applied to biological tissues and fluids is that it identifies the changes in redox processes that contribute to disease.
EPR spectroscopy has come a long way from its original use to detect malignant tumors. For example, the development and later refinement of methods of low-temperature registration of biological tissues widened the scope of EPR spectroscopy. Innovations made possible by the introduction of spin labels, probes, and traps made EPR spectroscopy ever more applicable to biochemistry and medicine, to the point where in vivo studies are being carefully considered.
This comprehensive book discusses spectra of many tissues and bodily fluids, and the quantitative nature of paramagnetic centers in both normal individuals and patients suffering from a variety of diseases. Special attention is given to the EPR examination of bio-molecules, such as enzymes, polypeptides, vitamins, lipids, hydrocarbons, etc., which play an essential role in human activity.
This book will be of great interest to physicians specializing in many different areas. Similarly, biologists, biochemists, biophysicists, and chemists will find this book very useful. It has also been written so that it may be used as a textbook at graduate level.

Spis treści

Acknowledgments. Preface. 1: Electron Paramagnetic Resonance (EPR): Theory and Method. 1.1. Fundamentals of the EPR Theory. 1.2. Procedures for Studying Paramagnetic Centers. 2: Paramagnetic Centers in the Human Biological Media. 2.1. Erythrocytes. 2.2. Blood Plasma. 2.3. Saliva. 2.4. Nasal Secretion. 2.5. Teeth. 2.6. Contents of the Stomach. 2.7. Duodenal Contents. 2.8. Synovial Fluid. 2.9. Feces. 3: Paramagnetic Centers in the Organism of Volunteers and Patients in Various Pathological States. 3.1. Biological Substrates of Normal Individuals. 3.2. Ischemic Heart Disease. 3.3. Hypertensive Disease. 3.4. Blood Diseases. 3.5. Hemostasis Disorder. 3.6. Diseases of Gastro-Intestinal Tract. 3.7. Lung Diseases. 3.8. Diseases of Kidneys. 3.9. Diabetes. 3.10. Nervous System Diseases. 3.11. Diseases of Joints and Connective Tissue. 3.12. Myoglobin Pathology. 3.13. Cutaneous Diseases. 3.14. Gynecologic Diseases. 3.15. Oncologic Diseases. 3.16. Ophthalmic Diseases. 3.17. Otorhinolaryngologic Diseases. 3.18. Diseases of Teeth and Mouth Cavity. 3.19. Radiation-Induced Pathology. 3.20. Hyperthermia in Pathologic States. 3.21. Hyperbaric Oxygenation. 3.22. Conditions under Narcosis. 3.23. Pathologic States Caused by Intoxication. 3.24. Sepsis-Induced States. 3.25. Peritonitis. 3.26. Acquired Immunodeficiency Syndrome (AIDS). 4: Other Aspects of EPR Investigation of Biological Specimens. 4.1. Food Products. 4.2. Drugs. 4.3. Forensic Medical Examination. 4.4. Archaeology. Conclusion. Abbreviations. Index.