Electrochemistry of Nucleic Acids and Proteins: Towards Electrochemical Sensors for Genomics and Proteomics Volume 1

ISBN-13: 9780444521507 / Angielski / Twarda / 2006 / 808 str.

Palecek E. Ed; E. Palecek; F. Scheller

Opis

DNA (sometimes referred to as the molecule of life), is the most interesting and most important of all molecules. Electrochemistry of Nucleic Acids and Proteins: Towards Electrochemical Sensors for Genomics and Proteomics is devoted to the electrochemistry of DNA and RNA and to the development of sensors for detecting DNA damage and DNA hybridization. Volume 1, in the brand new series Perspectives in Bioanalysis, looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century.

* Covers highly sophisticated methods of electrochemical analysis of nucleic acids and proteins
* Summarises the present state of electrochemical analysis of nucleic acids and proteins
* Includes future trends in the electrochemical analysis in genomics and proteomics

Spis treści

1. Polarography of DNA. Retrospective.

2. Electrochemical properties of nucleic acid components.

3. Electrochemistry of nucleic acids.

4. Electrochemical DNA biosensors.

5. Amplified electrochemical and photoelectrochemical analysis of DNA.

6. Fully electrical microarrays.

7. Carbon electrodes in DNA hybridization research.

8. Conducting polymers for DNA sensors and DNA chips; from fabrication to molecular detection.

9. Control of chloride ion exchange by DNA hybridization at polypyrrole electrode.

10. Threading intercalators as redox indicators.

11. Nanoparticle-based Electrochemical DNA Detection.

12. Detecting DNA damage with electrodes.

13. Sensors for genotoxicity and oxidized DNA.

14. Electrochemical immunoassays on the route to proteomic chips.

15. Self-Assembly of Biomolecules on Electrode Surfaces; Oligonucleotides, Amino Acids, and Proteins towards the Single-Molecule Level.

16. Direct electrochemistry of proteins and enzymes.

17. Amperometric enzyme sensors based on direct and mediated electron transfer.

18. Catalytic hydrogen evolution on mercury electrodes from solutions of peptides and proteins.

19. Electroactivity of proteins and its possibilities in biomedicine and proteomics.

Appendix: Methods in proteomics.

20. Polarography of proteins. A history.