Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3

ISBN-13: 9781489918154 / Angielski / Miękka / 2013 / 599 str.

Kenneth V. Honn;Lawrence J. Marnett;Santosh Nigam

Opis

This volume constitutes, in part, the proceedings of the Hong Kong Conference on "Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury" held in Hong Kong in October 1995. It contains papers by the symposium speakers, as well as poster contributions from researchers in this field. Since the discovery of "PROSTAGLANDIN-LIKE' substances 60 years ago. much has been learned. EICOSANOID is the new term that is used to include prostaglandins. thromboxanes, leukotrienes, lipoxins, isoprostanes, depoxilins, hydroxy acids, epoxy and hydroperoxy fatty acids. The conference focussed on recent development in underatanding the role of EICOSANOIDS in inflammation, cancer, and radiation damage. At the confer- ence, we also highlighted advances in newly developing areas such as "NO," "A POP- TOSIS and "ANANDAMIDE." The discovery of the structures of genes that encode several key enzymes and receptors of the Eicosanoid cascade, has allowed us to include reports in the "Alteration of the Gene Expression" section that reflects the most recent de- velopments in regulation for PGH-synthase and lipoxygenases. The editors are convinced that this volume will be an up-to-date and useful reference for investigators in both basic and clinical research.

Spis treści

Lipoxygenase: Studies on the Active Site of Leuktriene A4 Hydrolase; A. Wetterholm, et al. PGH Synthase: Disruption of the Mouse Cyclooxygenase I Gene: Characteristics of the Mutant and Areas of Future Study; R. Langenbach, et al. Alteration of Gene Expression: Characterization of Prostaglandin H Synthase-2 Deficient Mice and Implications for Mechanisms of NSAID Action; S.G. Morham, et al. Receptors: Structure and Regulation of Platelet Activating Factor Receptor Gene; T. Shimizu, H. Mutoh. Inflammation: PGE2 Regulation of B Lymphocytes and T Helper 1 and T Helper 2 Cells: Induction of Inflammatory Versus Allergic Response; E.R. Fedyk, et al. Signal Transduction: Plasma Membrane Guanylate Cyclase: A Multimodule Transduction System; R.K. Sharma, T. Duda. Anandamide: Anandamide Amidohydrolase from Porcine Brain: Partial Purification and Characterization; N. Ueda, et al. PAF: Cloning and Characterization of a Murine Platelet-Activating Factor Receptor Gene; S. Ishii, et al. Cell Growth and Apoptosis: Clinical Studies: Poster Sessions: 76 Additional Articles. Index.