Effect of crowdedness in the life cycle of Lysenin studied by HS-AFM

ISBN-13: 9783639560480 / Angielski / Miękka / 2017 / 128 str.

López de Blas Ignacio

Opis

Lysenin life cycle start with a soluble monomer that binds to membrane lipid sphingomyelin. After an oligomerization process Lysenin nonamers, known as prepores, suffer endocitosis. In the late endosome the acidic conditions induce the oligomer insertion, resulting in the so-call pore state. High-Speed Atomic Force Microscopy allow to study Lysenin life cycle, highlighting the crucial role of crowdedness in it.

O autorze

Ignacio López de Blas obtain has degre in Physics with the speciallity of Condensed Matter in the Autonomous University of Madrid. Was also in this university where he obtained his degree of Magister in Biophysics. Later he travelled to Marseille to develop a Philosophical Doctorate in Biophysics.