Drug Transporters

ISBN-13: 9783642145407 / Angielski / Twarda / 2011 / 454 str.

Martin F. Fromm

Opis

"Drug Transporters" provides an overview of the most important transporter families for drug therapy. Each chapter is dedicated to a different transporter family, discussing tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Spis treści

From the contents.- Preface.- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport