Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology

ISBN-13: 9781119588436 / Angielski / Twarda / 2022 / 528 str.

Stephen H. Curry; Robin Whelpton

Spis treści

Preface1 Setting the Scene: Concepts, Nature of Drugs and Quality of Results2 Drug Disposition and Fate3 Pharmacokinetic Modelling4 Pharmacokinetics of Metabolism and Excretion5 Quantitative Pharmacological Relationships6 Predictive Pharmacokinetics7 Disposition of Peptides and Other Biological Molecules8 Monoclonal Antibodies9 Drug Metabolism and Pharmacokinetics in Veterinary Sciences10 Factors Affecting Plasma Concentrations. Consideration of Special Populations.11 Pharmacogenetics, Pharmacogenomics and Precision Medicine12 Effects of Sex and Pregnancy on Drug Disposition and Pharmacokinetics13 Developmental Pharmacology and Age-related Phenomena14 Effects of Disease on Drug Disposition and Pharmacokinetics15 Role of Stereochemistry in Drug Disposition and Pharmacokinetics16 Drug Metabolism and Pharmacokinetics in Drug Interactions and Toxicity17 Drug Monitoring in Therapeutics18 From Antiquity to the Age of Artificial Intelligence: Reflections on the Past, Present and Future of Drug Disposition and PharmacokineticsIndex

O autorze

Stephen H. Curry, PhD, D.Sc. (Med.), has held professorial positions in Pharmacology, Physiology and Pharmaceutical Sciences at the Universities of London, Florida, and Rochester, as well as posts in the pharmaceutical industry. He is a Fellow of the Royal Pharmaceutical Society, and currently works in the field of technology transfer and translational science with a primary interest in aiding university scientists with commercialization of patented medically-significant discoveries. He is based in Rochester, New York.Robin Whelpton, PhD, has taught undergraduate and postgraduate students of medicine, dentistry, pharmacology, analytical toxicology, pharmaceutical chemistry, and biomedical sciences at Queen Mary, University of London.