Dopamine - Glutamate Interactions in the Basal Ganglia

ISBN-13: 9780367381974 / Angielski / Miękka / 2019 / 284 str.

Susan Jones

Opis

The basal ganglia are involved in complex brain functions and are implicated in numerous neurological and psychiatric disorders. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of dopamine and glutamate. Improved labeling, imaging, recording, and genetic manipulation approaches have yielded new information on how dopamine and glutamate interact to generate the circuit activity underpinning basal ganglia function. This volume synthesizes this research, presenting current insights on individual neurons and synapses, detailed circuit analysis, and learning and action functions of the basal ganglia. The book also discusses compromised dopamine–glutamate interaction in various disorders of basal ganglia function.

Spis treści

Metabotropic Glutamate Receptor–Dopamine Interactions in the Basal Ganglia Motor Circuit. Ionotropic Glutamate Receptors in the Basal Ganglia. Dopamine Receptors and their Interactions with NMDA Receptors. Synaptic Triad in the Neostriatum: Dopamine, Glutamate, and the MSN. Dopaminergic Modulation of Glutamatergic Synaptic Plasticity in Striatal Circuits: New Insights from BAC-Transgenic Mice. Striatal Acetylcholine–Dopamine Crosstalk and the Dorsal–Ventral Divide. Electrophysiology of the Corticostriatal Network In Vivo. Functional Organization of the Midbrain Substantia Nigra. Striatal Dopamine and Glutamate in Action: The Generation and Modification of Adaptive Behavior. Impaired Dopamine–Glutamate Receptor Interactions in Some Neurological Disorders. Index.

O autorze

Susan Jones