Development and validation of HPLC method for simultaneous quantitative determination of Azilsartan medoxomil potassium and Chlorthalidone in human pl

ISBN-13: 9783656863144 / Angielski / Miękka / 2015 / 80 str.

Vijay Ram; Hitendra S. Joshi; Paras P. Vekariya Rajesh Ram

Opis

Doctoral Thesis / Dissertation from the year 2014 in the subject Chemistry - Analytical Chemistry, grade: 3, Saurashtra University (Department of Chemistry), course: Ph.D., language: English, abstract: The objective of this work was to develop a simple, cost effective, rugged and a high throughput method for simultaneous estimation of Azilsartan and Chlorthalidone in human plasma. Solid phase extraction technique is introduced here for first time and its advantages are: (I) Short processing time, (II) Significant reduction in the labour and (III) This technique minimizes chances of errors, saves considerable time and simplifies the sample preparation methodology. The run time per sample analysis of 15.0 min suggests the high throughput of the proposed method. From the results of all the validation parameters, the method proposed here can be useful for therapeutic drug monitoring both for analysis of routine samples of single dose or multiple dose pharmacokinetics and also for the clinical trial samples.

O autorze

Dr. Vijay R. Ram has completed his Masters of Sciences in Analytical Chemistry and his Doctorate (Ph.D.) in Analytical Chemistry from Saurashtra University. His research area is Method Development and Validation of pharmaceutical drugs as well as in phytochemical investigation of natural plants. He published more than thirty research papers in this field. Currently he´s working as faculty in Department of Chemistry, KSKV Kachchh University, Bhuj-Gujarat, India, as an Assistant Professor.