Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part a: Volume 166

ISBN-13: 9780128168516 / Angielski / Twarda / 2019 / 424 str.

Vladimir Uversky

Spis treści

1. Protein intrinsic disorder and structure-function continuum Vladimir N. Uversky 2. Intrinsic disorder associated with 14-3-3 proteins and their partners Nikolai N. Sluchanko and Diego M. Bustos 3. Intrinsically disordered proteins and phenotypic switching: Implications in cancer Vivek Kulkarni and Prakash Kulkarni 4. Translational diffusion of unfolded and intrinsically disordered proteins Irina V. Nesmelova, Daria L. Melnikova, Venkatesh Ranjan and Vladimir D. Skirda 5. Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humans Anamika Avni, Hema M. Swasthi, Anupa Majumdar and Samrat Mukhopadhyay 6. Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases Orkid Coskuner and Vladimir N. Uversky 7. Shear-induced amyloid formation of IDPS in the brain Conrad N. Trumbore 8. Role of intrinsic disorder in muscle sarcomeres Dmitri Tolkatchev, Garry E. Smith Jr. and Alla S. Kostyukova 9. Computational prediction of functions of intrinsically disordered regions Akila Katuwawala, Sina Ghadermarzi and Lukasz Kurgan 10. The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1a along with its interacting proteins Neha Garg, Prateek Kumar, Kundlik Gadhave and Rajanish Giri

O autorze

Vladimir N. Uversky is a Professor at the Department of Molecular Medicine, University of
South Florida, USA. He obtained B.S. and M.S. degrees in Physics from Leningrad State
University in Russia in 1986, then completed Ph.D. and Doctor of Sciences (D.Sc.) degrees
in Physics and Mathematics (field of study - Biophysics) at the Moscow Institute of Physics and Technology (1991) and the Institute Experimental and Theoretical Biophysics of the Russian Academy of Sciences (1998), respectively. In 1998, he moved to the University of California Santa Cruz to study protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomena. In 2004, he was invited to join the Indiana University School of Medicine to primary work on intrinsically disordered proteins, and since 2010 has been on faculty at the University of South Florida. He has authored over 850 scientific publications and edited several books and book series on protein structure.