DNA Nanotechnology: From Structure to Functionality

ISBN-13: 9783030548056 / Angielski / Twarda / 2020 / 406 str.

Chunhai Fan; Yonggang Ke

Spis treści

Towards Active Self-assembly through DNA Nanotechnology.- Tailoring DNA self-assembly to build hydrogels.- DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials.- Engineering Functional DNA-Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications.- DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions.- Directional assembly of nanoparticles by DNA shapes: towards designed architectures and functionality.- Oligonucleotide-Polymer Conjugates: From Molecular Basic to Practical Application.- Biotechnological and Therapeutic Applications of Natural Nucleic Acid Structural Motifs.- DNA driven Nanoparticle Assemblies for Biosensing and Bioimaging.- Aptamer-functionalized DNA Nanostructures for Biological Applications.- High-performance biosensing based on autonomous enzyme-free DNA circuits.- DNA strand displacement reaction: a powerful tool for discriminating single nucleotide variants.

O autorze

​Chunhai Fan is a K. C. Wong Chair Professor at Shanghai Jiao Tong University (SJTU). Before joining SJTU, he was a CAS Distinguished Professor at the Shanghai Institute of Applied Physics, Chinese Academy of Sciences. He published over 400 papers in peer-reviewed journals. He is a fellow of Royal Society of Chemistry (FRSC), an elected fellow of the International Society of Electrochemistry (ISE) and American Association for the Advancement of Science (AAAS). His research interests include DNA nanotechnology, biosensing and bioimaging.

Yonggang Ke is an assistant professor at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. He received his Ph.D. degree in chemistry from Arizona State University in 2009. He then worked as a postdoctoral fellow in the Department of Cancer Biology at Harvard University from 2009 to 2014. Dr. Ke is one of the leading experts in DNA nanotechnology. His current research focuses on programmable self-assembly of complex nanostructures and dynamic nanomachines using DNA and other biomolecules, functional nanomaterial self-assembly, drug delivery, and single-molecule biophysics.

Blurb

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

The chapter "DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials" is available open access under a CC BY 4.0 License via link.springer.com.