DNA Damage and Repair

ISBN-13: 9781475750188 / Angielski / Miękka / 2013 / 383 str.

A. Castellani

Opis

The First International Congress on DNA Damage and Repair was held in Rome, Italy, July 12-17, 1987. It was organized by the Italian Com- mission for Nuclear Alternative Energy Sources. The subject of DNA damage and repair involves almost all the fields ofbidogical sciences. Some of the more prominent ones include carcino- genesis, photobiology, radiation biology, aging, enzymology, genetics, and molecular biology. These individual fields have their own interna- tional meetings and although the meetings often have sessions devoted to DNA repair, they do not bring together a wide diversity of international workers in the field to exchange ideas. The purpose of the Congress was to facilitate such an exchange among scientists representing many fields of endeavor and many countries. The 37 manuscripts in this volume, presented by the invited spea- kers during the four and half days of the Congress, encompass the field of DNA damage and repair. They cover biological systems ranging from mo- lecules to humans and deal with damages and repair after treatment of cells with various types of radiations, chemicals, and exogenous and en- dogenous oxidative damages. The Congress and its Proceedings are dedicated to two international leaders in the field of DNA damage and repair, Alexander Hollaender of the United States and Adriano Buzzati Traverso of Italy. Hollaender, who died in December 1986, was one of the first investigators to recognize the damage to DNA was important in cell killing and mutagenesis. His early work indicated that cells could recover from radiation injury.

Spis treści

Twenty Five Years of DNA Repair.- Macromolecular Physiology of the Escherichia Coli UVR Proteins.- Toward an Understanding of Nucleotide Excision Repair in Yeast: A Summary of Recent Progress.- Isolation and Characterization of Genes Involved in Mammalian Excision Repair.- Selective DNA Repair in the Transcribed Strands of Active Genes in Mammalian Cells.- Chromosomal Mapping of Human DNA Repair Genes.- Inhibiting DNA Repair — Models, Manipulations and Misconceptions.- The Association of Xeroderma Pigmentosum with Trichothiodystrophy: A Clue to a Better Understanding of XP-D?.- In Vitro Correction of Cells from Patients with Mutagen Hypersensitivity.- DNA Alkylation Adducts in Human Cells Attributable to Exposure to Alkylating Agents.- DNA Repair of Alkylation Damage and its Relevance to Mutation Fixation in Mammalian Cells.- Mechanisms of Alkylating Agent Induced Cytotoxicity in E. Coli and Mammalian Cells.- The Response of Human Cells to In Vivo Methylation Damage.- Repair of Secondary Lesions Arising in DNA After Treatment with Alkylating Agents.- Inducible Repair of Alkylated Bases in Mammalian Cells.- DNA Strand Bias During O6-Methylguanine Mutagenesis.- Formation and Enzymatic Repair of Specific Reaction Products of Alkylating N-Nitroso Carcinogens in Cellular DNA: Relevance to Malignant Transformation.- DNA Damage and Repair in Human Skin In Situ.- DNA Repair and Mutagenesis Induced by Dimer and Non-Dimer Photoproducts Measured with Plasmid Vectors in Xeroderma Pigmentosum Cells.- Molecular Mechanisms of Mutagenesis Induced by Chemical Carcinogens and Cis-DDP.- Maintenance of 5-Methylcytosine in Mammalian Cells by Specific Correction of G/T Mispairs in Favor of Guanine.- A Shuttle Vector for Investigating the Molecular Mechanisms of Mutagenesis in Mammalian Cells in Culture.- Mammalian DNA Ligase: Studies on the Structure and Function During DNA Replication and Repair.- Antineoplastic Agents Inhibitor of Topoisomerase II.- DNAase I Hypersensitive Sites of the c-Ha-ras-1 Proto-oncogene as Targets for Rapid Benzo(a)pyrene Binding and Repair.- Visualization and Computer-Assisted Quantification of DNA Modifications in Individual Cells.- A Short Review of Methods for Detecting DNA Fragmentation and Associated Phenomena.- DNA Unwinding: Common Modification Induced by “Bulky Adducts” to DNA Structure.- Mechanisms of Hydrogen Peroxide Cytotoxicity in Mammalian and Bacterial Cells.- Cancer, Aging, and Endogenous DNA Damage.- Processing of Thymine Glycols, Urea Residues and AP Sites in Escherichia Coli.- Low Dose Radiation Effects in Human Cells.- Multiple Roles for Poly(ADP-Ribose) Synthesis in Repair of DNA Damage and Malignant Transformation.- The Induction and Repair of Double-Strand DNA Breaks in Mammalian Cells as Detected by Neutral Elution.- Damage, Repair, and DNA Synthesis in Radiation Lethality of Mammalian Cells.- X-Rays Induced Double Strand Breaks: Damage Distribution and Measurement.- Killing, Stress Responses and Mutagenesis Induced in E. Coli by Hydrogen Peroxide.