Cyclic Peptide Design

ISBN-13: 9781493995066 / Angielski / Miękka / 2020 / 332 str.

Gilles Goetz

Opis

This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature's cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.

Spis treści

1. Design Principles for Intestinal Permeability of Cyclic Peptides

            Alan M. Mathiowetz

 

2. Strategies to Enhance Metabolic Stabilities

            Bhavesh Khatri, Venkateswara Rao Nuthakki, and Jayanta Chatterjee

 

3. Designing Cell-Permeable Macrocyclic Peptides

            George Appiah Kubi, Patrick G. Dougherty, and Dehua Pei

 

4. Computational Methods for Studying Conformational Behaviors of Cyclic Peptides

            Fan Jiang and Hao Geng

 

5. Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions

            Fergal Duffy, Nikunj Maheshwari, Nicolae-Viorel Buchete, and Denis Shields

 

6. Design of Cyclic Peptides as Protein Recognition Motifs

            Ye Che

 

7. Design and Synthetic Strategies for Helical Peptides

            Licheng Tu, Dongyuan Wang, and Zigang Li

 

8. Click Chemistry for Cyclic Peptides Drug Design

            Adel Ahmed Rashad

 

9. Frontier between Cyclic Peptides and Macrocycles

            Philipp Ermert, Anatol Luther, Peter Zbinden, and Daniel Obrecht

 

10. Building upon Nature’s Framework: Overview of Key Strategies towards Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles

            Maria-Jesus Blanco

 

11. Design of Oxytocin Analogs

            Kazimierz Wiśniewski

 

12. DNA-Encoded Macrocyclic Peptide Library

            Zhengrong Zhu, Alex Shaginian, LaShadric C. Grady, Christopher P. Davie, Kenneth Lind, Sandeep Pal, Praew Thansandote, and Graham L. Simpson

 

13. Peptide Display Technologies

            Anthony Pitt and Zeke Nims

 

14. Discovery of Functional Macrocyclic Peptides by Means of the RaPID System

            Christos Tsiamantas, Manuel E. Otero-Ramirez, and Hiroaki Suga

 

15. Genetic Selections with SICLOPPS Libraries: Towards the Identification of Novel Protein-Protein Interaction Inhibitors and Chemical Tools

            Francisco Castillo and Ali Tavassoli