Curcumin /Chitosan/CMC Composite Films for Antimicrobial Applications

ISBN-13: 9783659758652 / Angielski / Miękka / 2015 / 68 str.

Ahuja Sonam;Bajpai Sunil

Opis

A new technique, called vapor induced phase inversion (VIPI), has been employed to fabricate cellulose micro crystals(CMC) -loaded chitosan(Ch) films and curcumin loaded Chitosan/cellulose micro crystals (CMC) composite films. The method involves immediate exposure of CMC-dispersed chitosan solution to ammonia gas. The swelling ratio (SR) of films showed negative dependence on the cellulose content in the films. The dynamic water uptake data were interpreted by various kinetic models. The CMC-loaded chitosan film showed slower release as compared to the plain chitosan film, suggesting that cellulose micro crystals acted as diffusion barrier. The films were non cytotoxic, non thrombogenic and non-hemolytic. The Curcumin loaded films were investigated for their equilibrium moisture absorption behavior. The data obtained was interpreted by GAB isotherm model. The dynamic release of curcumin from the films was studied under physiological conditions and kinetic data was best interpreted by Higuchi model. The films showed fair antimicrobial action against bacteria and fungi.

O autorze

Sonam Ahuja is a research scholar of Polymer Research Lab, Govt.Model Science (Auto.)College Jabalpur (M.P.) India.She is working under the supervision ofDr.S.K. Bajpai. Her thesis title is "Cellulose Whiskers reinforced Polysaccharides based Antimicrobial Films". She has published two research paper in International Journals.