Coenzyme Q in Aging

ISBN-13: 9783030456412 / Angielski / Twarda / 2020 / 402 str.

Guillermo L?pez Lluch

Spis treści

Part 1. Basics on coenzyme Q

1. Introduction. The current coenzyme Q science and knowledge

Plácido Navas

2. Molecular structure, biosynthesis, and distribution of coenzyme Q

Luis Vázquez-Fonseca, Isabel González-Mariscal and Carlos Santos Ocaña

3. Coenzyme Q function in mitochondria

María Luisa Genova and Giorgio Lenaz

4. Extramitochondrial coenzyme Q₁₀ in aging

Guillermo López Lluch

5. Regulation of the synthesis of Coenzyme Q₁₀

María Victoria Cascajo Almenara and Guillermo López Lluch

 

Part 2. Coenzyme Q in aging studies.

6. Coenzyme Q and aging in C. elegans

Claudio Asencio Salcedo

7. Coenzyme Q and aging in the fruit fly Drosophila melanogaster

Daniel José Moreno Fernández-Ayala and Alberto Sanz

8. The aging process and coenzyme Q: clk-1 mouse models

Mayumi Takahashi, Kazuhide Takahashi and Takuji Shirasawa

9. Reduced coenzyme Q₁₀ decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions

Jinko Sawashita, Xu Zhe and Keiichi Higuchi

 

Part 3. Age-related diseases and coenzyme Q.

10. Coenzyme Q, mtDNA and mitochondrial dysfunction during aging

José Luis Quiles, Alfonso Varela-López, María Dolores Navarro-Hortal and Maurizio Battino

11. Coenzyme Q₁₀ and metabolic syndrome

Juan Diego Hernández-Camacho

12. Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases

Francisco J. Alcaín, Javier Domínguez, Mario Durán-Prado and Julia Vaamonde

13. Immunosenescence and CoQ₁₀

Juan Diego Hernández-Camacho, Catherine Meza-Torres and Guillermo López-Lluch

14. Coenzyme Q₁₀ in fertility and reproduction

Diana Vaamonde, Antony C. Hackney, Carolina Algar-Santacruz, María José García-Moreno and Juan Manuel García-Manso

 

Part 4. Prolongevity effectors and Coenzyme Q.

15. Calorie restriction, longevity and coenzyme Q

María Isabel Burón, Cristina Parrado, José Antonio González-Reyes, Lucía Fernández del Río, Elena Gutiérrez-Casado, Miguel Calvo-Rubio, Sandra Rodríguez-López and José Manuel Villalba.

16. Age dependent changes of coenzyme Q levels and its induction in experimental systems

Magnus Bentinger, Gustav Dallner, Kerstin Brismar, Ewa Swiezewska and Michael Tekle

17. Effects of coenzyme Q₁₀ supplementation on elderly people

Elena M. Yubero-Serrano, Francisco M. Gutierrez-Mariscal, José López-Miranda,

 

 

O autorze

Guillermo López Lluch Graduated in Biology at the University of Córdoba, Spain in July, 1992. PhD (Biology) at the University of Cordoba in July, 1997.
Professor at the Pablo de Olavide, Seville, from 1998 starting as Assistant professor and obtaining a position as Lecturer/Reader in May 2003.
Between June, 1999 and October, 2000 postdoctoral student granted with a Marie Curie Fellowship from the European Commission at the Department of Molecular Medicine (Rayne Institute), University College of London working on the biology of neutrophils under the supervision of Dr. Anthony W. Segal and Dr. Lodewijk V. Dekker.
From October, 2018, Full Professor in the Area of Cell Biology of the Department of Physiology, Anatomy and Cell Biology of this University. Further, Associate Researcher at the Andalusian Centre for Developmental Biology (CSIC-UPO-JA) at the same University.
Current research field: metabolic and antioxidant regulation during aging. The importance of metabolism and mitochondrial physiology is clear. Many prolongevity effectors regulate mitochondrial activity and turnover and affect endogenous antioxidant activities that seems to be coordinated with metabolism. The role of coenzyme Q and its enzymatic-dependent activities is important in this regulation and in the progression of aging and is the current focus of research. This research has produced 90 international publications, around 20 book chapters and more than 200 contributions to congresses including invited conferences.

Blurb

This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q₁₀ and the process of aging in living organisms. CoQ₁₀ is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ₁₀ is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging.

The book is organized in four sections. The first offers an overview of the function of CoQ_10, highlighting the two main functions of CoQ₁₀ in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants.

The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice.

Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction.

The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ₁₀ levels by induction of synthesis or by supplementation.

Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.