Clinical Significance of C-Reactive Protein

ISBN-13: 9789811567865 / Angielski / Twarda / 2020 / 313 str.

Waliza Ansar; Shyamasree Ghosh

Spis treści

A. Introduction

B. Structure and function of CRP

1. Single nucleotide polymorphisms and CRP

2. Structure of CRP, glycosylation, microheterogeneity

3. Serum proteins, acute phase response, inflammation

C. Clinical applications of CRP

4. Clinical role of CRP in diagnostics and therapeutics

5. Clinical role of glycosylated serum proteins

D. CRP in selected diseases

6. CRP and autoimmune diseases and role in rheumatoid arthritis

7. CRP and  pediatric diseases

8. CRP and neurodegenerative disorders

9. CRP and tuberculosis

10. CRP in sepsis, ICU and ITU patients

11. CRP and cardiac diseases

12. CRP and Parasitic diseases

13. CRP and respiratory diseases

14. CRP and diabetes

15. CRP and cancer

O autorze

Dr. Waliza Ansar holds a Bachelor’s degree in Zoology (Honors) with Chemistry and Botany and a Master’s degree in Zoology from Calcutta University. She was awarded the National Scholarship in 1994. She was awarded her Ph.D. degree (2009) from CSIR- Indian Institute of Chemical Biology, Kolkata, Govt of India, after qualifying for the State Level Eligibility Test (SLET) and National Eligibility Test (NET) conducted by the Ministry of CSIR-HRDG, Govt of India . In her Ph.D work, she demonstrated various biological roles of CRP in malaria, leishmaniasis and tuberculosis. She also completed three years of postdoctoral research at CSIR-IICB, India. She has worked as a lecturer (2002-2003) in Zoology, and is currently an Assistant Professor  of Zoology) at Behala College, Kolkata, where she was the Head of the department of Zoology from 2015-2017. She has also worked at Asutosh College, Kolkata as a lecturer in Environmental Science and Zoology. She has conducted research on dipteran flies, and has published papers on CRP and therapeutic applications of monoclonal antibodies in journals such as Glycoconjugate, Cellular Physiology and Biochemistry, Immunology research, the Indian Journal of Clinical Medicine, and Journal of Stem Cells. She has also published a book chapter on nanomedicine, and a book on C-reactive protein. She has presented her work at various international and national symposiums. 

Dr. Shyamasree Ghosh is currently a Scientific Officer (F) at the School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar. She graduated from the Presidency College Kolkata in 1998 with Hons in Zoology with Chemistry and Physiology and was awarded a prestigious National Scholarship from the Govt. of India. She received her postgraduate degree in Biotechnology from Calcutta University, ranking second at the University in the year 2000. She completed her Ph.D. the field of childhood acute lymphoblastic leukemia (ALL) at the Indian Institute of Chemical Biology, under CSIR, Kolkata, after qualifying for the National Eligibility Test conducted by the Ministry of HRD, Govt of India. Her work was accepted in various national and international journals of repute and is cited by the young researchers worldwide. She worked in the field of stem cells and nanotechnology in her post-doctoral Research. Later she joined as a faculty in post graduate college affiliated to Bangalore University. She has worked and published in Computational Immunology and Machine Learning. She has authored several publications that include books from international  publishers of repute including Springer, Elsevier, CRC Press, De Gryter and encyclopedia chapters.

Blurb

This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology.

Divided into 5 sections, the book examines important topics such as the role of CRP in neurodegenerative, cardiac and parasitic diseases, as well as in cancer and inflammatory bowel disease, and the expression of CRP in pediatric respiratory diseases. In addition it discusses the clinical role of CRP in diagnostics and therapeutics, sepsis, ICU and ITU patients, and also as a primary marker for inflammation. Given its scope, this book will appeal to scholars in various fields of medicine and biology.