Circular Dichroism and the Conformational Analysis of Biomolecules

ISBN-13: 9780306451423 / Angielski / Twarda / 1996 / 738 str.

Gerald D. Fasman; G. D. Fasman

Opis

''Excellent and very timely....It will undoubtedly become a standard reference for the application of circular dichroism (CD) to biomolecules.'' --- Quarterly Review of Biology, March 1997 '' T]estament to the book's utility is the fact that during the course of my review I had to 'rescue' it from the desks of graduate students on an almost daily basis. In summary, this is a great book.'' --- American Scientist ''Well documented chapters provide a very good insight into the problems surrounding the conformation of biomacromolecules...An indispensible source of information.'' --- Nahrung, 42(2), 1998 Renowned experts present the first state-of-the-art description of circular dichroism spectroscopy (CD). Chapters present in-depth discussions of the history of the field, the theory of CD for application to globular proteins, membrane proteins, peptides, nucleic acids and their interactions, carbohydrates, and instrumentation. Discussions also feature new techniques using synchrotron radiation, vibrational Raman optical activity, and vibrational CD. More than 250 illustrations supplement the text.

Spis treści

Remembrance of Things Past: A Career in Chiroptical Research (J.T. Yang). Theory of Circular Dichroism of Proteins (R.W. Woody). Determination of Protein Secondary Structure (S.Y. Venyaminov, J.T. Yang). Aromatic and Cystine Sidechain Circular Dichroism in Proteins (R.W. Woody, A.K. Dunker). Stoppedflow Circular Dichroism (K. Kuwajima). Circular Dichroism of Collagen and Related Polypeptides (R.S. Bhatnagar, C.A. Gough). CD Spectroscopy and the Helixcoil Transition in Peptides and Polypeptides (N.R. Kallenbach et al.). The £Ii£ Sheet=Coil Transition of Polypeptides: As Determined by Circular Dichroism (L. Tilstra, W.L. Mattice). Turns (A. Perczel, M. Hollósi). Differentiation between Transmembrane Helices and Peripheral Helices by the Deconvolution of Circular Dichroism Spectra of Membrane Proteins (G.D. Fasman). Theories of Circular Dichroism for Nucleic Acids (D. Keller). Determination of the Conformation of Nucleic Acids by Electronic CD (W.C. Johnson, Jr.). Circular Dichroism of Proteinnucleic Acid Interactions (D.M. Gray). Carbohydrates (E.S. Stevens). Chaperones (G.D. Fasman). Vibrational Circular Dichroism: Applications to Conformational Analysis of Biomolecules (T.A. Keiderling). Circular Dichroism Using Synchrotron Radiation: From Ultraviolet to Xrays (J.C. Sutherland). Circular Dichroism Instrumentation (W.C. Johnson, Jr.). Vibrational Raman Optical Activity of Biomolecules (L.D. Barron et al.). 252 illustrations. Index.