Cholesterol Transport Systems and Their Relation to Atherosclerosis

ISBN-13: 9783540505488 / Angielski / Miękka / 1989 / 112 str.

Armin Steinmetz; Hans Kaffarnik; Ja1/4rgen Schneider

Opis

A number of clinical and epidemiological studies have shown that disorders of lipoprotein metabolism constitute one of the most important risk factors for the development of atherosclerosis and coronary heart disease. This volume examines the state of the art of lipoprotein subclass metabolism and its relation to these diseases. The authors also report on new developments concerning the role of lipoprotein recptors, macrophages and apolipoprotein E polymorphism in cholesterol homeostasis. The combination of general outline form and very specific aspects of cholesterol transport will interest those in other disciplines following developments in the field, as well as those directly involved in lipoprotein research.

Spis treści

Regulation of Cholesterol Metabolism.- Receptors in the Regulation of Cholesterol Metabolism.- Apolipoprotein E Modulates the Metabolism of Apolipoprotein B Containing Lipoproteins by Multiple Mechanisms.- Regulation of Macrophage Cholesterol Homeostasis.- Hypercholesterolemia, LDL- and Scavenger Pathway.- Familial Combined Hyperlipidemia Workshop.- Lipoproteins and Atherosclerosis: Lessons from an Animal Model for Familial Hypercholesterolemia.- Use of RFLPs of the LDL Receptor Gene in Diagnosis of Familial Hypercholesterolaemia.- Lipoprotein Lp (a) Structure and Metabolism.- Genetic Polymorphism of Lipoprotein (a).- Binding Sites for Modified Low-Density Lipoprotein on Macrophagocytic Cells: Implications for Atherogenesis?.- Removal of Low-Density Lipoproteins by Alternative Pathways.- Reverse Cholesterol Transport.- Reverse Cholesterol Transport.- Antiatherogenic Effect of Apolipoprotein A-I Containing Lipoproteins.- An Apo A-I Protein a Hybrid Used for the Study of HDL Receptor Binding and Endocytosis.- Lipid Transfer Protein: Hyperalphalipoproteinemia and Cholesteryl Ester Transfer/Exchange Activity.- Role of Apolipoprotein A-IV in Reverse Cholesterol Transport.

O autorze

Dr. Jürgen Schneider, geboren 1934 in Frankfurt am Main, Dipl.-Bauingenieur, verheiratet, zwei Kinder. Bis 1982 als Geschäftsführer in der väterlichen Baufirma tätig, danach Aufbau eines Milliardenimperiums als privater Bauinvestor. 1994 Flucht nach Miami und Zusammenbruch der Firma, 1997 Strafprozess wegen Betrugs, Ende 1999 nach Verbüßung von zwei Dritteln seiner Strafe entlassen.