Chiral Separations: Methods and Protocols

ISBN-13: 9781627032629 / Angielski / Twarda / 2013 / 531 str.

Gerhard K. E. Scriba

Opis

There is a demand for analytical methods that are able to discriminate between enantiomers in order to analyze the enantiomeric purity of compounds from natural or chemical sources not only in pharmaceutical sciences but in any field on bioactive compounds including chemistry, biology, biochemistry, forensic, and environmental sciences and many others. The second edition of Chiral Separations: Methods and Protocols, expands upon the previous edition with current methodology, providing an overview and especially practically oriented applications of the most important analytical techniques in chiral separation sciences. New chapters on analytical separation sciences by chromatographic and electrophoretic techniques have been added as has simulated moving bed chromatography as a preparative method. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chiral Separations: Methods and Protocols, Second Edition is helpful for analytical chemists working on stereochemical problems in fields or pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences or cosmetics in academia, government or industry.

Recenzje

From the reviews of the second edition:

"The second edition of Chiral Separations: Methods and Protocols discusses almost every kind of chiral separation method, with the emphasis on fundamental research and experimental design. ... it is a very useful book for scientists and students involved in the enantioseparation field, and scientists involved in R & D areas such as drug development and environmental monitoring can also benefit from this monograph. It is expected that this book will definitely promote research in chirality-related fields." (Huwei Liu, Analytical and Bioanalytical Chemistry, Vol. 406, 2014)

"The book provides an overview and practically oriented applications of the most important analytical techniques in chiral separations. ... the chapters include introductions, lists of necessary materials and reagents, step-by-step laboratory protocols, and troubleshooting tips. Pharmacists, biochemists, chemists, food chemists, molecular biologists, and forensic and environmental scientists will find this book extremely useful." (Omer Iqbal, Doody's Book Reviews, August, 2013)

Spis treści

 1. Chiral Recognition in Separation Science – An Overview

Gerhard K. E. Scriba

2. Enantioseparations by Thin-Layer Chromatography

Massimo Del Bubba, Leonardo Checchini, Alessandra Cincinelli and Luciano Lepri

 

3. Gas Chromatographic Enantioseparation of Unfunctionalized Chiral Hydrocarbons - An Overview

Volker Schurig, Diana Kreidler

 

4. HPLC-Enantioseparation on Cyclodextrin-based Chiral Stationary Phases

Yong Wang and Siu Choon Ng

 

5. Enantioseparations by High Performance Liquid Chromatography Using Polysaccharide-Based Chiral Stationary Phases – An Overview

Bezhan Chankvetadze

 

6. Common Screening Approaches for Efficient Analytical Method Development in LC and SFC on Columns Packed with Immobilized Polysaccharide-derived Chiral Stationary Phases

Pilar Franco and Tong Zhang

7. Chiral Separations by HPLC on Immobilized Polysaccharide Chiral Stationary Phases
Imran Ali, Zeid A. AL-Othman, and Hassan Y. Aboul-Enein

 

8. Enantioseparations by High-Performance Liquid Chromatography Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases – An Overview

István Ilisz, Anita Aranyi, Zoltán Pataj, Antal Péter

 

9. Enantioseparations of Primary Amino Compounds by High Performance Liquid Chromatography Using Chiral Crown Ether-Based Chiral Stationary Phase

Myung Ho Hyun

10. Screening of Pirkle-type Chiral Stationary Phases for HPLC Enantioseparations

Gregory K. Webster and Ted J. Szczerba

 

11. Enantioseparations by High Performance Liquid Chromatography Based on Chiral Ligand Exchange

Benedetto Natalini, Roccaldo Sardella, Federica Ianni

 

12. Enantioseparations by High Performance Liquid Chromatography Using Molecularly Imprinted Polymers

David A. Spivak

 

13. Chiral Mobile Phase Additives in HPLC Enantioseparations

Shengjia Wang, Lushan Yu, Su Zeng

14. Chiral Benzofurazan-Derived Derivatization Reagents for Indirect Enantioseparations by HPLC

Toshimasa Toyo'oka

 

15. Separation of Racemic 1-(9-anthryl)-2,2,2-trifluoroethanol by Sub-/supercritical Fluid Chromatography

Xiqin Yang, Leo Hsu and Gerald Terfloth

 

16. Chiral Separations by Simulated Moving Bed Method Using Polysaccharide-Based Chiral Stationary Phases

Toshiharu Minoda

17. Enantioseparations by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors

Gerhard K. E. Scriba and Pavel Jáč

 

18. Application of Dual Cyclodextrin-Systems in Capillary Electrophoresis Enantioseparations

Anne-Catherine Servais and Marianne Fillet

 

19. Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins

Anne-Catherine Servais and Marianne Fillet

 

20. Use of Macrocyclic Antibiotics as the Chiral Selectors in Capillary Electrophoresis

Chengke Li, Jingwu Kang

21. Application of Polymeric Surfactants in Chiral Micellar Electrokinetic Chromatography (CMEKC) and CMEKC Coupled to Mass Spectrometry

Jun He and Shahab A. Shamsi

 

22. Cyclodextrin-modified Micellar Electrokinetic Chromatography for Enantioseparations

Wan Aini Wan Ibrahim, Dadan Hermawan and Mohd Marsin Sanagi

 

23. Cyclodextrin-mediated Enantioseparation in Microemulsion Electrokinetic Chromatography

Claudia Borst and Ulrike Holzgrabe

 

24. Chiral Separations by Capillary Electrophoresis Using Proteins as Chiral Selectors

Jun Haginaka

25. Enantioseparation by Chiral Ligand-Exchange Capillary Electrophoresis

Yi Chen, Lijuan Song

 

^{26. Experimental Design Methodologies in the Optimization of Chiral CE or CEC Separations – An Overview}

^{Bieke Dejaegher, Debby Mangelings, and Yvan Vander Heyden}

 

^{27. Chiral Capillary Electrophoresis-Mass Spectrometry}

 

^{Elena Domínguez-Vega, Antonio L. Crego, Maria Luisa Marina}

 

^{28. Application of Chiral Ligand-Exchange Stationary Phases in Capillary Electrochromatography}

^{Martin G. Schmid}

29. Polysaccharide-Derived Chiral Stationary Phases in Capillary Electrochromatography Enantioseparations

Zhenbin Zhang, Hanfa Zou and Junjie Ou

 

30. Open Tubular Molecular Imprinted Phases in Chiral Capillary Electrochromatography

Won Jo Cheong and Song Hee Yang

 

31. Enantioseparations in Capillary Electrochromatography Using Sulfated Poly b-Cyclodextrin Modified Silica-Based Monolith as Stationary Phase

Ruijuan Yuan and Guosheng Ding

 

32. Cyclodextrin-Mediated Enantioseparations by Capillary Electrochromatography

Dorothee Wistuba and Volker Schurig

Blurb

There is a demand for analytical methods that are able to discriminate between enantiomers in order to analyze the enantiomeric purity of compounds from natural or chemical sources not only in pharmaceutical sciences but in any field on bioactive compounds including chemistry, biology, biochemistry, forensic, and environmental sciences and many others. The second edition of Chiral Separations: Methods and Protocols, expands upon the previous edition with current methodology, providing an overview and especially practically oriented applications of the most important analytical techniques in chiral separation sciences. New chapters on analytical separation sciences by chromatographic and electrophoretic techniques have been added as has simulated moving bed chromatography as a preparative method. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and cutting-edge, Chiral Separations: Methods and Protocols, Second Edition is helpful for analytical chemists working on stereochemical problems in fields or pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences or cosmetics in academia, government or industry.