Chemoreception: From Cellular Signaling to Functional Plasticity

ISBN-13: 9780306478680 / Angielski / Twarda / 2003 / 633 str.

Jean-Marc Pequignot; Constancio Gonzalez; Colin A. Nurse

Opis

Since 1959, the International Society of Arterial Chemoreception (ISAC) has organized in a variety of countries fifteen scientific meetings devoted to the mechanisms of peripheral arterial chemoreception and chemoreceptor reflexes. After the meeting held in Philadelphia with Sukhamay Lahiri as president, ISAC membership elected Lyon (CNRS, University Claude Bernard, France) as the site of the xv" ISAC Symposium. The Symposium was effectively held in Lyon from the 18th to the 22nd of November 2002 and Jean-Marc Pequignot was its president. The organizers were Jean-Marc Pequignot and Yvette Dalmaz Lyon (CNRS, University Claude Bernard, France) and the Scientific Committee was formed by John Carroll (University of Arkansas for Medical Sciences, USA), Constancio Gonzalez (University of Valladolid, Spain), Prem Kumar (University of Birmingham, U. K. ), Sukhamay Lahiri (University of Pennsylvania, Philadelphia, USA), Colin Nurse (McMaster University, Hamilton, Ontario, Canada), and Nanduri Prabhakar (Case Western University, Cleveland, Ohio, USA). The Symposium in Lyon intended to follow the path opened in Philadelphia gathering people working at the interface of cellular and molecular biology with researchers in the more classical topics of chemoreception pathways and reflexes. The aim was to join experts with different perspectives. Along these lines, some participants are engaged in the exploration of the intimate mechanisms of oxygen sensing and cellular responses, with their work centered in a great number of preparations covering a broad spectrum from bacteria, to chemoreceptor cells or to central nervous systems neurons.

Spis treści

Honoring Pierre Dejours. His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humans; H. Gautier. O2 and CO2 Sensing Mechanisms in the Peripheral Arterial Chemoreceptors: Membrane Properties, Intracellular Metabolic and Genomic Events. 2P Domain K+ Channels: Novel Pharmacological Targets for Volatile General Anesthetics; A.J. Patel, E. Honore. Ca2+ Responses to Hypoxia are Mediated by IP3-R on Ca2+ Store Depletion; S. Lahiri, et al. Functional Identification of Kvalpha Subunits Contributing to the O2-sensitive K+ Current in Rabbit Carotid Body Chemoreceptor Cells; J.R. López-López, et al. Carotid Body Chemoreceptor Activity in Mice Deficient in Selected Subunits of NADPH Oxidase ; L. He, et al. Glucose Sensing Cells in the Carotid Body; M. Garcia-Fernandez, et al. Effect of Mitochondrial Inhibitors on Type I Cells; C.N. Wyatt, K.J. Buckler. Ascorbate in the Carotid Body; A. Dymecka, et al. Studies on Glomus Cell Sensitivity to Hypoxia in Carotid Body Slices; P. Ortega-Sáenz, et al. An Unusual Cytochrome a592 with low PO2 Affinity Correlates with Afferent Discharge in the Carotid Body; C. Huckstorf et al. A Reevaluation of the Mechanisms Involved in the Secretion of Catecholamine Evoked by 2.4 Dinitrophenol From Chemoreceptors Cells of the Rabbit Carotid Body; A. Rocher, et al. Enhancing Effect of Vasopressin on the Hyperglycaemic Response to Carotid Body Chemoreceptor Stimulation. 6 Additional Articles. O2 and CO2 Sensing Mechanisms in Airway Chemoreceptors, Pulmonary Artery Smooth Muscle Cells and Other Oxygen-sensing Systems: MembraneProperties, Intracellular Metabolic and Genomic Events. Pulmonary Interstitium: an Introductory Review; G. Miserocchi. Regulation of K+ Currents by CO in Carotid Body Type 1 Cells and Pulmonary Artery Smooth Muscle Cells; P. Kumar, et al. Ionotropic Receptors in Pulmonary Neuroepithelial Bodies (NEB) and their Possible Role in Modulation of Hypoxia Signalling; E. Cutz, et al. Mitochondrial Complex II is Essential for Hypoxia-induced ROS Generation and Vasoconstriction in the Pulmonary Vasculature; R. Paddenberg, et al. Regulation of the Hypoxia-inducible Transcription Factor HIF-1 by Reactive Oxygen Species in Smooth Muscle Cells; S. BelAiba, A. Görlach. O2-sensing Mechanisms in Efferent Neurons to the Rat Carotid Body; V.A. Campanucci, et al. Amyloid Peptide-mediated Hypoxic Regulation of Ca2+ Channels in PC12 Cells; C. Peers, et al. Role of ROS and NO in Hypoxia-induced Increase in Tyrosine Hydroxylase-messenger RNA in PC12 Cells; W. Kummer, et al. Oxygen Sensing by Human Recombinant Tandem-P Domain Potassium Channels; P.J. Kemp, et al. Oxygen Sensing by Human Recombinant Large Conductance Calcium-activated Potassium Channels: Regulation by Acute Hypoxia; P.J. Kemp, et al. Potential Oxygen Sensing Pathways in the Zebrafish Gill; M.G.Jonz, et al. 3 Additional Articles. Mechanisms of Communication Between Chemosensory Cells and Chemoafferent Fibers. Dye and Electric Coupling Between Carotid Nerve Terminals and Glomus Cells; R.G. Jiang, C. Eyzaguirre. Neurotransmitter Relationships in the Hypoxia-challenged Cat Carotid Body; R.S. Fitzgerald, et al.Ach Differentially Modulates Voltage-gated K Channels in Glomus Cells between DBA/2J and A/J Strains of Mice; S. Yamaguchi, et al. Hypoxic Augmentation of Neuronal Nicotinic