Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

ISBN-13: 9783319181431 / Angielski / Twarda / 2015 / 395 str.

Philip K. Moore; Matt Whiteman

Opis

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

Spis treści

Part I Biochemistry, molecular biology and chemistry.- 1 H₂S synthesizing enzymes: biochemistry and molecular aspects.- Part II Molecular mechanisms of action.- 2 Sulfhydration and H₂S.- 3 Persulfide formation and H₂S.- Part III Cardiovascular system.- 4 H₂S and blood vessels - an overview.- 5 Hydrogen sulfide and urogenital tract.- 6 H₂S - cardiac function and cardiac disease.- 7 H₂S and platelets – a possible role in thrombosis?.- Part IV Inflammation and inflammatory disease.- 8 H₂S and inflammation  - an overview.- 9 H₂S and neuroinflammation.- Part V H₂S and the nervous system.- 10 Brain, learning and memory: role in neurodegenerative diseases.- 11 H₂S and pain – inflammatory and neuropathic.- Part VI H₂S, angiogenesis and cancer.- 12 H₂S and colon cancer.- 13 The role of H₂S in cancer and tumor development.- Part VII H₂S and ageing.- 14 H₂S – a new approach to lifespan enhancement and healthy aging?.- Part VIII H₂S, measurement and possible therapeutics?.- 15 Measurement of H₂S – probes comes of age?.- 16 S-propargylcysteine – a novel H₂S donor with therapeutic potential.- 17 Mitochondria-targetted sulfide donors.- 18 Medicinal chemistry - insights into the development of novel H₂S donors.