Ceramide Signaling

ISBN-13: 9780306474422 / Angielski / Twarda / 2003 / 162 str.

Anthony H. Futerman; Anthony H. Futerman

Opis

This volume assembles up-to-date information on the role of ceramide as a signalling molecule in 16 chapters. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atheriosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling.

Spis treści

Foreword. Preface. 1. Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass Spectronomy; A.H. Merrill Jr., et al. 2. Ceramide in Apoptosis: Possible Biophysical Foundations of Action; P.K.J. Kinnunen, J.H. Holopainen. 3. Ceramide-Mediated Receptor Clustering; E. Gulbins, H. Grassmé. 4. Ceramidases: Regulators of Turnover of Ceramide and Ceramide-Mediated Responses; C. Mao, L. Obeid. 5. Molecular Evolution of Neutral Ceramidase: From Bacteria to Mammals; M. Ito, et al. 6.The Role of Cerine/Threonine Protein Phosphatases in Ceramide Signaling; C.E. Chalfant, Y.A. Hannun. 7. Kinase Suppressor of Ras as a Ceramide-Activated Protein Kinase; D.B. Polk, et al. 8. Ceramide in Apoptosis: The FAN Thesis, Not a Fantasy; B. Ségui, et al. 9. The Cross-Talk Between Nitric Oxide and Ceramide; R. Barsacchi, et al. 10. Crosstalk of Ceramide with Cell Survival Signaling; T. Okazaki, et al. 11. Ceramide in the Regulation of Neuronal Development: Two Faces of a Lipid; C. Riebeling, A.H. Futerman. 12. Neurons, Neurotrophins and Ceramide Signaling: Do Domains and Pores Contribute to the Dichotomy? R.T. Dobrowsky. 13. Ceramide Signaling in Cannabinoid Action; I. Galve-Roperh, et al. 14. Ceramide Glycosylation and Chemotherapy Resistance; M.C. Cabot. 15. Ceramide in Serum Lipoproteins: Function and Regulation of Metabolism; M.N. Nikolova-Karakashian. 16. TherapeuticImplications of Ceramide-Regulated Signaling Cascades; M. Kester, et al. Index.