Central Nervous System Diseases and Inflammation

ISBN-13: 9780387738932 / Angielski / Twarda / 2007 / 318 str.

Thomas E. Lane; Monica Carson; Conni Bergmann

Opis

Up until approximately 20 years ago, the idea that the central nervous system (CNS) and components of the immune system were dynamically interactive was considered impossible (or at least highly unlikely) as the CNS was judged an immunosuppressive environment based upon experimental evidence highlighting the survival of tissue grafts within the brain. Additional evidence supporting this viewpoint included (i) the presence of the blood brain barrier (BBB) which p- vides a physical and physiological obstruction that is difficult for cells and mac- molecules to cross, (ii) the relative absence of MHC class I and II expression on CNS cells like astrocytes and neurons, and (iii) lack of abundant antigen presenting cells (APC) which are required for the generation of an adaptive immune response. However, in spite of these obstacles, it is now well-accepted that the CNS is r- tinely subject to immune surveillance under both normal as well as diseased con- tions. Indeed, activated cells of the immune system such as T and B lymphocytes and monocyte/macrophages readily infiltrate and accumulate within the CNS f- lowing microbial infection, injury, or upon development of autoimmune responses directed toward resident antigens of the CNS."

Recenzje

From the reviews:

"The involvement of the immune system in central nervous system diseases is highlighted in this book, which details important advances in the understanding of certain aspects of neuroinflammation. ... This is clearly appropriate for clinicians and researchers who are interested in neuroinflammation in the central nervous system. It also can be a valuable research guide for students who are interested in learning some basics on this topic. ... It makes worthwhile contributions to this area." (Christine Maria Rohowsky-Kochan, Doody's Review Service, September, 2008)

Spis treści

Microglia: A CNS-Specific Tissue Macrophage.- Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments.- Pericytes.- Imaging Microglia in the Central Nervous System: Past, Present and Future.- Cytokines in CNS Inflammation and Disease.- Arachidonic Acid Metabolites: Function in Neurotoxicity and Inflammation in the Central Nervous System.- Pattern Recognition Receptors in CNS Disease.- Central Nervous System Diseases and Inflammation.- Chemokines and Autoimmune Demyelination.- Chemokine Actions in the CNS: Insights from Transgenic Mice.- Chemokines and Spinal Cord Injury.- The Usual Suspects: Chemokines and Microbial Infection of the Central Nervous System.- CNS Dendritic Cells in Inflammation and Disease.- MHC Class I Expression and CD8 T Cell Function: Towards the Cell Biology of T-APC Interactions in the Infected Brain.

Blurb

This volume serves as a succinct and well-organized reference volume focused on inflammatory CNS disease to a wide audience. The text is comprised of four sections revolving around current areas of interest in the fields of neuroimmunology, virology, pharmacology and disease. Sections of this text focus on a specific category of diseases as well as the pharmacological, virological, and immunological effects of and on the disease.

Although many have covered this topic, few have provided a volume as concise and efficient. Each disease is broken down on a variety of scientific levels without getting into the history of the disease. This approach provides a succinct overview of a specific subject encompassing interrelated topics pertaining to neurology, immunology and disease. The information provided in Central Nervous System Diseases and Inflammation will be useful for researchers, clinicians, as well as a valuable resource for students interested in the fascinating arena of neuroinflammation.