Cellular Nanomachines: From Discovery to Structure-Function and Therapeutic Applications

ISBN-13: 9783030444952 / Angielski / Twarda / 2020 / 109 str.

Bhanu P. Jena

Spis treści

Introduction

Chapter 1. Porosome: Cells Secretory Nanomachine

-Discovery

-Structure

-Isolation and Composition

-Functional Reconstitution

-Altered Porosome Proteins in Secretory Defects and disease

Chapter 2. Ubiquitin-Proteasome Machinery: Cells Garbage Disposal

-Discovery

-Structure-Function

-Disease Treatments Targeting Proteasome

Chapter 3. Chaperonin: Protein Folding Machinery in Cells

-Discovery

-Structure-Function

-Disease Resulting from Alteration in Chaperonin

Chapter 4. ATP Synthase: Energy Generator of the Cell

-Discovery

-Structure-Function

-Disease Resulting from Altered ATP Synthase

Chapter 5. Ribosome: Cells Protein Synthetic Machinery

-Discovery

-Structure-Function

-Ribosome Defects in Disease

Chapter 6. Nuclear Pore: A Bidirectional Transport Machinery

-Discovery

-Structure-Function

-Defects in Nuclear Transport and Disease

Chapter 7. Myosin: Cellular Molecular Motor

-Discovery

-Structure-Function

- Disease resulting from altered motor protein

-Diagnosis of Myopathy: Current and and Future

Chapter 8. Assembly of Cellular Nanomachines

O autorze

Bhanu P. Jena is George E. Palade University Professor & Distinguished Professor of Physiology at Wayne State University School of Medicine, and Director of the NanoBioScience Institute. In 1996 while an Assistant Professor at Yale University School of Medicine, he discovered the ‘porosome’, a new cellular nanomachine that serves as the secretory portal in cells. Prof. Jena is the recipient of numerous awards and honours, among them six honorary doctorates, the Aaron Klug Award, Palade Gold Medal, and AAAS Fellow. He received his Ph.D. from Iowa State University followed by postdoctoral training as a Swebilius Fellow at Yale University. 

Blurb

In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them. The major focus of this book is the “porosome” nanomachine, the universal secretory portal in cells. This is an ideal book for students, researchers, and professionals in the fields of nanoscience and nanotechnology.