Cellular Mechanisms of Sensory Processing: The Somatosensory System

ISBN-13: 9783642787645 / Angielski / Miękka / 2011 / 502 str.

Laszlo Urban

Opis

This volume is a multi-disciplinary characterization of the somatosensory system - a field that has experienced revolutionary changes in recent years through the accumulation of basic and clinical data. For example, the discovery of the interaction between the nervous system and the immune system has changed our view on the development of inflammatory diseases, while the cloning of genes encoding different trophic factors boosted studies revealing profound changes in the regeneration of neurones, and the induction of changes in phenotype.

Spis treści

Characterization of The Primary Afferent.- Diversity of Somatic Spikes in Dorsal Root Ganglion Cells: Implications for Development, Function and Plasticity.- Ion Channels Underlying Transduction and Adaptation in Mechanoreceptors.- Signal Transduction Processes in Sensorimotor Neurones of the Enteric Nervous System.- Modulation of Voltage Dependent Calcium Channels by GABAb Receptors and G Proteins in Cultured Rat Dorsal Root Ganglion Neurons: Relevance to Transmitter Release and Its Modulation.- Signal Integration in the Axon Tree Due to Branch Point Filtering Action.- Polymodality in Nociceptive Neurons: Experimental Models of Chemotransduction.- Chemical Excitation and Sensitization of Nociceptors.- Local Effector Functions of Primary Afferent Nerve Fibers.- Transmitters in the Somatosensory System (Synaptology of the Spinal Cord).- Exitatory Amino Acid Receptors in the In Vitro Mammalian Spinal Cord.- Modulation of NMDA Currents in Hippocampal Neurons.- Excitatory Amino Acid Receptors in the Spinal Cord.- Excitatory Amino Acid Release in Dorsal Root Ganglion Cultures.- The Involvement of Excitatory Amino Acids and their Receptors in the Spinal Processing of Nociceptive Input from the Normal and Inflamed Knee Joint in the Rat.- Tachykinin Receptors and their Antagonists.- Synaptic Activation by the Release of Peptides.- TRH and Substance P Increase Rat Motoneurone Excitability through A Block of A Novel K+ Conductance.- Dynamic Changes in the Sensory System.- Influences of the Chemical Environment on Peripheral Afferent Neurons.- Silent Primary Afferents.- Sensory Neurons and Plasticity: The Role of Immediate Early Genes.- Molecular Biology of Dynorphin Gene Expression in Relationship to Spinal Cord Processing of Pain.- Regulation of Cellular Phenotype in the Nociceptive Pathway.- Altered Functions of Neuropeptides and Nitric Oxide in Somatosensory Afferents and Spinal Cord After Peripheral Nerve Lesions in the Rat.- Hyperexcitabilty in the Spinal Dorsal Horn: Cooperation of Neuropeptides and Excitatory Amino Acids.- The Role of Nitric Oxide in Hyperalgesia.- Dynamic Changes in Dorsal Horn Neurons.- Postsynaptic Changes During Sustained Primary Afferent Fiber Stimulation as Revealed by C-Fos Immunohistochemistry in the Rat Spinal Cord.- Structural Plasticity of Primary Afferent Terminals in the Adult Dorsal Horn — Regenerative Sprouting Induced by Peripheral Nerve Injury.