Cell Surface Grp78, a New Paradigm in Signal Transduction Biology

ISBN-13: 9780128123515 / Angielski / Miękka / 2018 / 144 str.

Salvatore V. Pizzo

Opis

There are many books which review "classic" cell surface receptor biology; however, a new paradigm has emerged in the past dozen years with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, no such effort has been directed towards presenting the "story" of cell surface GRP78. This book will do just that.

• Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies
• In-depth treatment of the biological underpinnings of GRP78 and its connection to disease
• Four-color illustrations facilitate the narrative

Spis treści

1. Introduction to the Discovery of the Endoplasmic Reticulum Chaperone GRP78 on the Cell Surface 2. The Endoplasmic Reticulum Chaperone GRP78 also Functions as a Cell Surface Signaling Receptor 3. Cell surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in Cancer 4. Cell Surface GRP78: A Targetable Marker of Cancer Stem-like Cells 5. Cell Surface GRP78 Regulates the Pro-Coagulant Activity of Tissue Factor 6. GRP78 Modulates the Plasminogen Activating System in the Brain: Implications for Human Disease 7. Escherichia coli Subtilase Cleaves Cell Surface GRP78 preventing COOH-terminal Signaling

O autorze

Studies from Pizzo's laboratory identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies. Cell surface GRP78 functions as a signaling receptor promoting tumor proliferation and suppressing apoptosis. Patients with a number of malignancies mount an autoimmune response to GRP78 and these antibodies, which bind to the NH2 terminal domains of GRP78, are receptor agonists whose appearance is a marker of poor prognosis. More recently, his lab has shown that antibodies directed against the COOH-terminal domain of GRP78 are receptor antagonists which may have therapeutic potential for treating patients whose tumors express GRP78 on the cell surface.