Cardiac Adaptations: Molecular Mechanisms

ISBN-13: 9781461452027 / Angielski / Twarda / 2012 / 466 str.

Bohuslav Ostadal; Naranjan S. Dhalla

Opis

This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation. Particular attention is paid to the still underestimated adaptive cardiac responses during development, to adaptation to the frequently occurring pressure and volume overload as well as to cardiac changes, induced by enduring exercise and chronic hypoxia. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.

Spis treści

Part A    DEVELOPMENTAL ASPECTS OF CARDIAC ADAPTATION

1.  Comparative Aspects of Cardiac Adaptation
 Bohuslav Ostadal

2. Molecular Mechanisms in Cardiac Development
 Patricia Roche, Michael P. Czubryt, Jeffrey T. Wigle

3.  Prenatal Adaptation to Overload
 Zivorad Pesevski, David Sedmera

4. Hypoxia and Mechanical Factors Drive Coronary Vascular Development
 Robert J. Tomanek

5.  Cardiac Metabolic Adaptation During Postnatal Development
 Jérôme Piquereau, Marta Novotna, Anne Garnier, Frédéric. Joubert, Vladimir Veksler, Renée Ventura-Clapier

6.  Ontogenetic Adaptation to Chronic Hypoxia
 Bohuslav Ostadal, Ivana Ostadalova, Zuzana Charvatova, Frantisek Kolar

7. Heart and Arterial Aging
 Paul D. Chantler, Edward G. Lakatta

Part B    CARDIAC ADAPTATIONS TO OVERLOAD

8.  Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy
 Alison L. Müller, Naranjan S. Dhalla

9.  Cardiac Adaptation to Volume Overload
 Vojtech Melenovsky

10. Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females
 Melissa R. Dent, Vijayan Elimban, Amrit Malik, Paramjit S. Tappia, Naranjan S. Dhalla

11. Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations
 Feriel Azibani, Claude Delcayre, Jane-lise Samuel

12. Cardiopulmonary Adaptation to High Altitude
 Jean-Paul Richalet

13. Cardiac Hypertrophy in Hypertension
 Jaroslav Kuneš, Ivana Vaněčková, Michaela Kadlecová, Michal Behuliak, Zdenka
 Dobešová, Josef Zicha,

14.  Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice
 Dirk J. Duncker, Elza D. van Deel, Monique C. de Waard, Jolanda van der Velden

15. The Athlete’s Heart
 Aaron L. Baggish

Part C   MOLECULAR AND CELLULAR ASPECTS OF CARDIAC ADAPTATIONS

16. Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy
 Adriana Adameova, Paramjit S. Tappia, Naranjan S. Dhalla

17. Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy
 Paramjit S. Tappia, Adriana Adameova, Naranjan S. Dhalla

18. Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart
 Michael Wagner, M.A.Q. Siddiqui

19. Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy
 Vinod B. Pillai, Mahesh P. Gupta

20. Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection
 Enn Seppet, Ehte Orlova, Teet Seene, Frank N. Gellerich

21. Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor
 Morris Karmazyn, Xiaohong Tracey Gan

22. Myocardial Adaptation and Autophagy
 Dipak K. Das, Hannah R. Vasanthi

23. Modulatory Role of VEGF in Angiogenesis for Cell Survival
 Dipti Gatne, Veeranjaneyulu Addepalli, Dev D. Santani

24. The Role of CaM Kinase II in Cardiac Function in Health and Disease
 Adriana Adameova, Adrian Szobi, Slavka Carnicka, Tanya Ravingerova, Tomas Rajtik

Blurb

The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. 

The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging.  The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations.  The third section of this volume highlights the roles of sympathetic nervous system with respect to α-adrenoceptor and β-adrenoceptor mechanisms in the development of cardiac hypertrophy.  Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.