Carbohydrates: Synthesis, Mechanisms, and Stereoelectronic Effects

ISBN-13: 9780387922645 / Angielski / Twarda / 2009 / 560 str.

Momcilo Miljkovic

Opis

All essential areas of basic synthetic carbohydrate chemistry are covered and appropriately described. In addition, this book explains the basic reaction mechanisms while taking into account modern concepts such as stereoelectronic principles.

Recenzje

From the reviews:

"This book represents a compendium of methods and principles used in the field of synthetic carbohydrate chemistry. Useful information concerning basic aspects of the subject, such as nomenclature, conformational analysis, and anomeric effects, is easily available to the reader and is well presented ... . The book can still serve as a good source of literature references from the early days of carbohydrate chemistry ... ." (Alexei V. Demchenko, Journal of the American Chemical Society, Vol. 132 (45), 2010)

Spis treści

Conformational Analysis of Monosaccharides.- Anomeric Effect.- Isomerization of Sugars.- Relative Reactivity of Hydroxyl Groups in Monosaccharides.- Cyclic Acetals and Ketals.- Nucleophilic Displacement and the Neighboring Group Participation.- Anhydrosugars.- Amino Sugars.- Oxidation of Monosaccharides.- Addition of Nucleophiles to Glycopyranosiduloses.- Chemistry of the Glycosidic Bond.- Synthesis of Polychiral Natural Products from Carbohydrates.- Carbohydrate-Based Antibiotics.- Higher-Carbon Monosaccharides.

Blurb

Carbohydrates: Synthesis, Mechanisms, and Stereoelectronic Effects explains the conformational, electrostatic, and stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. Topics include the anomeric effect, the chemistry of the glycosidic bond, isomerization of free carbohydrates in aqueous solutions, relative reactivity of hydroxyl groups in carbohydrate molecules, and the addition of nucleophiles to glycopyranosiduloses. Focus then shifts to the synthesis of glycosidic bonds and oligosaccharides, the synthesis of anhydro and amino sugars, branched chain sugars and the protection of hydroxyl groups in monosaccharides. The last three chapters are devoted to areas often overlooked in carbohydrate chemistry textbooks: carbohydrate based antibiotics, synthesis of polychiral natural products from carbohydrates, and the chemistry of higher-carbon sugars.