Carbohydrate Recognition: Biological Problems, Methods, and Applications

ISBN-13: 9780470592076 / Angielski / Twarda / 2011 / 440 str.

Binghe Wang; Geert-Jan Boons

Opis

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Spis treści

PREFACE.

CONTRIBUTORS.

1 MAMMALIAN GLYCAN BIOSYNTHESIS: BUILDING A TEMPLATE FOR BIOLOGICAL RECOGNITION (M. Adam Meledeo, Venkata D. P. Paruchuri, Jian Du, Zhiyun Wang, and Kevin J. Yarema).

2 THE ROLES OF CARBOHYDRATE BINDING IN CELL ADHESION AND INFLAMMATION (Ken Kitajima and Chihiro Sato).

3 THE ROLE OF CARBOHYDRATES IN VIRAL INFECTIONS (Gillian M. Air).

4 THE ROLE OF CARBOHYDRATES IN BACTERIAL INFECTIONS (Roland J. Pieters).

5 THE ROLES OF CARBOHYDRATE BINDING IN FERTILIZATION (David J. Miller).

6 CARBOHYDRATE BIOMARKERS (Yunfeng Cheng, Nanting Ni, Hanjing Peng, Shan Jin, and Binghe Wang).

7 GALECTINS AND THEIR ROLE IN VARIOUS BIOLOGICAL PROCESSES (Sarika Saraswati, Ashley Stanley Block, and Alan B. Diekman).

8 GLYCOIMMUNOLOGY (Ani Grigorian and Barbara Newton).

9 TOOLS FOR GLYCOMICS: GLYCAN AND LECTIN MICROARRAYS (Jeff Gildersleeve).

10 COMBINATORIAL BIOSYNTHESIS OF COMPLEX CARBOHYDRATES (Hai Yu and Xi Chen).

11 MASS SPECTROMETRY IN CARBOHYDRATE SEQUENCING AND BINDING ANALYSIS (Gregory O. Staples and Joseph Zaia).

12 SYNTHETIC LECTIN MIMICS ARTIFICIAL CARBOHYDRATE RECEPTORS (Xiaochuan Yang, Yunfeng (Jerry) Cheng, and Binghe Wang).

13 LECTIN BINDING AND ITS STRUCTURAL BASIS (Annabelle Varrot, Bertrand Blanchard, and Anne Imberty).

14 MULTIVALENCY IN CARBOHYDRATE BINDING (Mark L. Wolfenden and Mary J. Cloninger).

15 CARBOHYDRATE BINDING AGENTS: POTENTIAL THERAPEUTICS WITH MULTIPLE INHIBITORY ACTIONS AGAINST ENVELOPED VIRUSES (K.O. Francois and J. Balzarini).

16 INFORMATICS FOR GLYCOBIOLOGY AND GLYCOMICS (Kiyoko F. Aoki–Kinoshita).

INDEX.

O autorze

BINGHE WANG, PhD, is Professor and Chair of the Department of Chemistry at Georgia State University as well as Georgia Research Alliance Eminent Scholar in Drug Discovery. He is Editor–in–Chief of the journal Medicinal Research Reviews, Series Editor for the Wiley Series in Drug Discovery and Development, and editor of Drug Delivery: Principles and Applications and Chemosensors: Principles, Strategies, and Applications (Wiley).

GEERT–JAN BOONS, PhD, is Franklin Professor of Chemistry and Professor in the Complex Carbohydrate Research Center at the University of Georgia. He is on the editorial boards of several journals on carbohydrates, including European Journal of Chemistry and Journal of Carbohydrate Chemistry, and is also coeditor of Carbohydrate–Based Immunotherapies and Vaccines (Wiley).

Blurb

The chemistry and biology of carbohydrates together in one book

Edited by renowned carbohydrate chemists, Binghe Wang and Geert–Jan Boons, with contributions from interdisciplinary scientists from around the world, Carbohydrate Recognition: Biological Problems, Methods, and Applications brings together in one place a wealth of information addressing the issue of targeting carbohydrate identification.

Carbohydrate recognition plays a role in a number of cellular functions and diseases, and this book is a significant step in aiding the development of drugs and other therapies by explaining the functions of carbohydrates in biological systems and their roles as drug targets.

Including chapters on biomarkers and cancer, bacterial and viral infections, mass spectrometry for sequencing and analysis, biosynthesis, informatics, and much more, Carbohydrate Recognition covers biological problems involving structural factors mediating carbohydrate recognition, the design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and the modulation of biological and pathological processes through carbohydrate recognition.