Carbohydrate-Modifying Biocatalysts

ISBN-13: 9789814241670 / Angielski / Twarda / 2011 / 846 str.

Peter Grunwald

Opis

Carbohydrates have long been disregarded by the scientific community due to their complex structure and a lack of suitable experimental methods for structure determination. This book provides an overview of the structure, function, and application of carbohydrate-modifying biocatalysts. It explores glycoconjugates and carbohydrate-modifying enzymes and the key roles they play in biological processes such as recognition, signal transduction, and immune responses. It discusses research activities in glycoscience, including the development of several new pharmaceuticals to treat malaria, cancer, and other diseases.

Recenzje

"This is an excellent compilation of the latest research in the field of carbohydrate-modifying biocatalysts written by highly recognized experts in the field. With glycoscience and biocatalysis emerging as fundamental contributors to a diverse array of scientific disciplines ranging from pharmaceutical development to renewable energy, this book is particularly timely and should serve as an excellent reference for inspiring scientists and students."
—Prof. Jon S. Thorson - University of Wisconsin School of Pharmacy, USA

Spis treści

Basics in Carbohydrate Chemistry. Glycoconjugates: An Overview. Oligosaccharides and Glycoconjugates in Recognition Processes. Glycoside Hydrolases. Disaccharide Phosphorylases: Mechanistic Diversity and Application in Glycosciences. Enzymatic and Chemo-Enzymatic Synthesis of Nucleotide Sugars: Novel Enzymes, Novel Substrates, Novel Products, and Novel Routs. Iteratively Acting Glycosyltransferases. Bacterial Glycosyltransferases Involved in Molecular Mimicry of Mammalian Glycans. Sulfotransferases and Sulfatases: Sulfate Modification of Carbohydrates. Glycosylation in Health and Disease. Sialic Acid Derivatives, Analogs and Mimetics as Biological Probes and Inhibitors of Sialic Acid Recognizing Proteins. Enzymes of the Carbohydrate Metabolism and Catabolism for Chemoenzymatic Syntheses of Complex Oligosaccharides. From Gene to Product — Tailor-Made Oligosaccharides and Polysaccharides by Enzyme and Substrate Engineering. Synthesis and Modification of Carbohydrates via Metabolic Pathway Engineering in Microorganisms. Metabolic Pathway Engineering for Hyaluronic Acid Production. Microbial Rhamnolipids. Chitin-Converting Enzymes: Linear and Cyclic Oligosaccharides. Fungal Degradation of Plant Oligo- and Polysaccharides. Bacterial Strategies for Plant Cell Wall Degradation and Their Genomic Information. Design of Efficient Multi-Enzymatic Reactions for Cellulosic Biomass Processing.

O autorze

Peter Grunwald