CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes

ISBN-13: 9789048137787 / Angielski / Twarda / 2010 / 338 str.

Bernard Perbal; Annick Perbal; Masaharu Takigawa

Opis

The 5th international workshop on the CCN family of genes was held in Toronto in 2008. This book comprises a series of manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology. It covers major aspects of CCN proteins biology in normal and pathological conditions.

Spis treści

Index CCN Proteins 1 Introduction Bernard Perbal 2 Report on the Fifth International Workshop on the CCN Family of Genes AE Irvine, B Perbal, H Yeger 3 Asking the right questions: What can the structure of the CCN protein domains tell us? Kenneth P. Holbourn, Bernard Perbal and K. Ravi Acharya 4 Nucleophosmin/B23: A muntifunctional regulator that determines the fate of CCN2 mRNA Satoshi Kubota, Yoshiki Mukudai, Harumi Kawaki, Seiji Kondo, Takanori Eguchi, Kumi Sumiyoshi, Toshihiro Ohgawara, Tsuyoshi Shimo and Masaharu Takigawa 5 Importance of CCN1/Cyr61 and CCN2/CTGF gene regulation and protein activities in mechanical force-driven developmental and pathological events in distensible organ systems Mary Hanna and Brahim Chaqour 6 A monoclonal antibody approach to CCN5 domain analysis Lan Wei, Frank Mckeon, Joshua W. Russo, Joan Lemire and John Castellot 7 Matricellular protein CCN2 produced by tubular epithelial cells plays a pivotal role in renal fibrogenesis Hirokazu Okada, Tsutomu Inoue and Hiromichi Suzuki 8 Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3 Masaharu Takigawa, Harumi Kawaki, Satoshi Kubota, Karen M. Lyons and Bernard Perbal 9 Role of CCN3 in bone marrow stromal cells Ken-ichi Katsube, Yuko Katsuki, Tasuku Kihara, Masanori Terai, Akihiro Umezawa, Kei Sakamoto and Akira Yamaguchi 10 Role of connective tissue growth factor in cardiac fibrosis Daiji Kawanami, Saptarsi M. Haldar and Mukesh K. Jain 11 Gene expression of CCN family members in young and aged human skin in vivo Taihao Quan, Sharon Shin, Zhaoping Qin, Gary J. Fisher 12 Global expression profiling reveals a role for CTGF/CCN2 in lactogenic differentiation of mouse mammary epithelial cells Weihan Wang, Cynthia Jose, Nicholas Kenney, Bethanie Morrison and Mary Lou Cutler 13 CCN3 (NOV): A negative regulator of CCN2 (CTGF) activity and an endogenous inhibitor of fibrosis in experimental diabetic nephropathy Bruce. L. Riser, Feridoon Najmabadi, Bernard Perbal, Jo Ann Rambow, Melisa L. Riser, Ernest Sukowski, Herman Yeger and Sarah C. Riser, and Darryl R. Peterson 14 Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo David R. Brigstock 15 Cell type-specific regulation of CCN2 protein expression by PI3K–AKT–FoxO signaling Jana Samarin, Iwona Cicha and Margarete Goppelt-Struebe 16 CCN3 promotes melanoma progression by regulating integrin expression, adhesion and apoptosis induced by cytotoxic drugs Viviana Vallacchi, Maria Daniotti, Annamaria De Filippo, Licia Rivoltini, Bernard Perbal and Monica Rodolfo 17 CCN3: A NOVel Growth Factor in Leukaemia Lynn Mc Callum and Alexandra E Irvine 18 Prognostic relevance of CCN3 in bone sarcomas Bernard Perbal, Noureddine Lazar, Diana Zambelli, Monia Zuntini, Massimo Serra, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Piero Picci, Katia Scotlandi 19 CCN6 regulates breast cancer growth and invasion through modulation of IGF signaling and epithelial to mesenchymal transition Anupama Pal, Wei Huang and Celina G. Kleer 20 Novel Transcriptional Regulation of CCN2/CTGF by Nuclear Translocation of MMP3 Takanori Eguchi, Satoshi Kubota, Kazumi Kawata, Yoshiki Mukudai, Junji Uehara, Toshihiro Ohgawara, Soichiro Ibaragi, Akira Sasaki, Takuo Kuboki and Masaharu Takigawa 21 Abstracts and Posters of the Fifth

Blurb

The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors.

The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types.

The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information.

The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology.

All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions.

In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes.

Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.