Breast Diseases: Breast-Conserving Therapy, Non-Invasive Lesions, Mastopathy

ISBN-13: 9783642735257 / Angielski / Miękka / 2011 / 548 str.

Fred Kubli; Dietrich V. Fournier; H. Junkermann

Opis

Important contributions about the treatment modalities of breast cancer are presented in this book. The risks and limitations of breast conserving therapy of mammary carcinoma are dealt with. Newest findings show that this form of therapy has the same outcome as conservative treatment modalities. The book also considers controversial issues such as the treatment of mastopathy, precancerous, and non-invasive lesions of the breast. New, but not yet approved, regimes for the prevention of mammary carcinoma and open questions concerning adequate operative treatment are discussed. Latest results presented here show that all modern palliative chemotherapy has a certain but limited effect on outcome and that early detection and preventive therapy (surgical and hormonal) will be of great importance for improved chances of survival of breast cancer.

Spis treści

I. Biology, Morphology, Growth Behavior.- Epidemiology of Breast Cancer.- Breast-Cancer Biology and Breast-Preserving Surgery.- S Phase Fractions and DNA Ploidy as Prognostic Factors in Breast Cancer.- Multicentricity in Breast Carcinoma.- The Contralateral Breast: Bilateral Primary Breast Cancer.- Cell Biology of Tumor Metastasis Formation.- Prognostic Factors in Primary Breast Cancer.- Natural Growth Rate of Primary Breast Cancer and its Metastases.- Growth Rates and Cytokinetic Behavior of Breast Cancer.- II. Diagnosis.- The Value of Diagnostic Methods: Mammography, Screening and Other Imaging Techniques.- Standards in the Technique of Mammography.- Current Status of Ultrasound Mammography.- Cytologic Diagnosis of Breast Cancer.- III. Primary Treatment.- Growth Behavior and Implications for Staging and Therapy.- Rationale for the Choice of Treatment.- Perioperative Clarification of Diagnosis.- Surgical Treatment.- Breast-Conserving Therapy or Amputation with Reconstruction: The Patient’s View.- Surgical Techniques of Breast Preservation for Early Breast Cancer.- Conservation Trials in Early Breast Cancer.- Surgical Complications After Conservative Treatment of Breast Cancer.- IV. Radiology.- Status of Radiotherapy after Ablative and Breast-Preserving Treatment of Breast Cancer.- Treatment of Breast Cancer with Breast Preservation.- First Experiences in Wurzburg of Interstitial Low-Dose Afterloading for Breast-Conserving Therapy with the Microselectron.- V. Results.- Long-Term Survival Following Breast-Conserving Therapy in Comparison to Radical Surgical Treatment: An Overview.- Breast-Conserving Treatment: Experience Derived from the National Surgical Adjuvant Breast Project.- Local Recurrence After Breast-Conserving Treatment: Results from the Harvard Joint Center for Radiation Therapy.- Local Recurrence and New Primary Ipsilateral Carcinomas After Conservative Treatment of Breast Carcinoma.- Pathoanatomical Characteristics of Local Treatment Failure Following Breast-Conserving Therapy.- Selective Issues in the Evaluation of the Efficacy of Breast-Conserving Therapy.- VI. Complications.- Long-Term Complications of Surgery and Associated Irradiation as Breast-Conserving Therapy.- Long-Term Complications of Breast-Conserving Treatment: Experience with the Basel Lumpectomy Protocol.- The German Breast Cancer Study I: Preliminary Results of Breast-Conserving Treatment Dependent on Radiation Technique.- Long-Term Results and Late Complications After Breast-Preserving Therapy of Breast Cancer in Vienna.- Possible Risk of Second Primary Cancers Associated with Irradiation in Breast-Conserving Therapy.- Psychological Problems of Women with Carcinoma of the Breast and Possible Means of Treatment.- Side Effects and Major Complications of Breast-Conserving Therapy.- Cosmetic Aspects of Breast-Conserving Therapy for Carcinoma of the Breast.- VII. Adjuvant Chemotherapy and Hormonal Therapy — Results and Complications.- The Integration of Radiotherapy and Chemotherapy in the Treatment of Early Breast Cancer.- Adjuvant Endocrine Treatment With and Without Simultaneous Adjuvant Chemotherapy.- Complication Rates of Radiotherapy with Adjuvant Chemotherapy for Conservative Treatment.- VIII. Strategies for the Prevention of Invasive Breast Cancer: Treatment of Mastopathic, Precancerous and Non-Invasive Lesions.- Diagnosis and Classification of Benign Breast Diseases.- Fibrocystic Disease, Precancerous Lesions, and Carcinoma In Situ: Characteristic Morphology and Risk of Malignant Degeneration.- Multicentricity of Ductal Carcinoma In Situ.- Precancerous Lesions and Carcinoma In Situ: Problems of Treatment from the Morphological Viewpoint.- Endocrinological Profiles in Benign Breast Disease.- Endocrinology of Benign Breast Disease in Relation to the Severity of Radiological Dysplasia.- Hormonal and Non-Hormonal Medical Therapy of Benign Breast Disease.- Medical Treatment of Benign Breast Disease.- In Situ Carcinoma of the Female Breast: Frequency, Growth Pattern and Biologic Significance.- DNA Synthesis Rate and Ploidy in Precancerous and Non-Invasive Lesions of the Breast.- Pathoanatomical Findings in Subcutaneous Mastectomy Specimens Referred to the Indications for Surgery.