Biomolecular Interfaces: Interactions, Functions and Drug Design

ISBN-13: 9783319168494 / Angielski / Twarda / 2015 / 372 str.

Fern; Ariel Fernandez Stigliano

Opis

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Spis treści

The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology.- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water.- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches.- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface.- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation.- Evolution of Protein Structure Degradation and Lessons for the Drug Designer.- Chemical Functionality of the Aqueous Interface in Soluble Proteins.- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy.- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer.- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine.- Controlling Induced Folding Through Wrapping Drug Design.- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology.- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology.- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment.- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design.- Epilogue.- Appendix 1. Code for Dehydron Identification.- Appendix 2. Solutions of Problems.

O autorze

The author is Ariel Fernandez Stigliano, who is an Argentinian–American theoretical chemist and mathematician, and heads his own pharmaceutical consultancy, Ariel Fernandez Innovation, at the Argentine National Scientific and Technical Research Council (CONICET) and at Collegium Basilea, the Institute of Advanced Study in Basel, Switzerland. Addresses: Avenida del Libertador 1092 – Piso 1 Buenos Aires 1112, Argentina 1419 Montrose Blvd. #305 Houston, TX 77019, USA Current Positions: * Senior Investigator, Argentine National Research Council (CONICET) (2011-). Instituto Argentino de Matemática, “Alberto P. Calderón", 1083 Buenos Aires, Argentina * Honorary Investigator, Collegium Basilea, Institute of Advanced Study, CH 4053 Basel, Switzerland (2006-) * Visiting Professor, National Tsing-Hua University, Hsinchu, Republic of China (2010-) · President, AF Innovation, SRL, a Pharmaceutical Consultancy (2010-). * Vice president and Chief Scientific Officer at Ariel Fernandez Consultancy, GmbH, a Biotechnology firm specialized in dynamic molecular design (2013-)