Biological Effects of Low Level Exposures Dose-Response Relationships

ISBN-13: 9781566700931 / Angielski / Twarda / 1994 / 320 str.

Edward J. Calabrese; Calabrese J. Calabrese

Opis

Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature.
The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.

Spis treści

Historical, Philosophical, Conceptual Foundations of BELLE Research: Includes four chapters of introductory material. Biological Effects of Low Level Exposure to Chemicals: Nonmonotonic Dose-Response Relationships in Toxicological Studies. Biostatistical Approaches to Low Level Exposures. Responses in Humans to Low Level Exposures. Cellular and Molecular Foundations of Hormetic Mechanisms. Modulation of Toxicity by Diet: Implications for Response at Low Level Exposures. Biological Effects of Low Level Exposure to Radiation: What Can be Learned from Epidemiologic Studies of Persons Exposed to Low Doses of Radiation? Positive Health Effects of Low Level Radiation in Human Populations. Test of the Linear-No Threshold Theory of Radiation Carcinogenesis. Bayesian Estimation of Incidence Change-Points in Low Dose Experimental and Epidemiologic Studies. Radiation-Induced Carcinogenesis: Paradigm Considerations. Stress Proteins and Radiation. Adaptive Responses After Exposure to Low Dose Radiation. BELLE Conference Perspectives and Summary: Synopsis of the BELLE Conference on Chemicals and Radiation. New Perspectives on Dose-Response Relationships and Low Level Exposures. BELLE Conference: A Summary.
Appendix. List of Acronyms and Abbreviations. List of Contributors. Index.

O autorze

Edward J. Calabrese