Bioinformatics Research and Applications: 5th International Symposium, Isbra 2009 Fort Lauderdale, Fl, Usa, May 13-16, 2009, Proceedings

ISBN-13: 9783642015502 / Angielski / Miękka / 2009 / 356 str.

Ion Mandoiu

Opis

The5th editionof the InternationalSymposium onBioinformaticsResearchand Applications (ISBRA 2009) was held during May 13-16, 2009 at Nova Sou- eastern University in Ft. Lauderdale, Florida. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and prac- tioners working on all aspects of bioinformatics and computational biology and their applications. The technical program of the symposium included 26 contributed papers, selected by the Program Committee from a number of 55 full submissions - ceived in response to the call for papers. The technical program also included contributed papers and abstracts submitted to the Second Workshop on C- putational Issues in Genetic Epidemiology (CIGE 2009), which was held in c- junction with ISBRA 2009. Additionally, the symposium included poster s- sions and featured invited keynote talks by four distinguished speakers: Mikhail Gelfand from the Russian Academy of Sciences and Moscow State University spoke on evolution of regulatory systems in bacteria, Nicholas Tsinoremas from the Miller School of Medicine and the College of Arts and Sciences at the U- versity of Miami spoke on bioinformatics challenges in translational research, Esko Ukkonen from the University of Helsinki spoke on motif construction from high-throughputSELEXdata, andShamil SunyaevfromBrighamand Women's Hospital and Harvard Medical School spoke on interpreting population seque- ing data. We would like to thank the Program Committee members and external - viewers for volunteering their time to review and discuss symposium papers.

Spis treści

Evolution of Regulatory Systems in Bacteria (Invited Keynote Talk).- Integrating Multiple-Platform Expression Data through Gene Set Features.- Practical Quality Assessment of Microarray Data by Simulation of Differential Gene Expression.- Mean Square Residue Biclustering with Missing Data and Row Inversions.- Using Gene Expression Modeling to Determine Biological Relevance of Putative Regulatory Networks.- Querying Protein-Protein Interaction Networks.- Integrative Approach for Combining TNF?-NF?B Mathematical Model to a Protein Interaction Connectivity Map.- Hierarchical Organization of Functional Modules in Weighted Protein Interaction Networks Using Clustering Coefficient.- Bioinformatics Challenges in Translational Research.- Untangling Tanglegrams: Comparing Trees by Their Drawings.- An Experimental Analysis of Consensus Tree Algorithms for Large-Scale Tree Collections.- Counting Faces in Split Networks.- Relationship between Amino Acids Sequences and Protein Structures: Folding Patterns and Sequence Patterns.- Improved Algorithms for Parsing ESLTAGs: A Grammatical Model Suitable for RNA Pseudoknots.- Efficient Algorithms for Self Assembling Triangular and Other Nano Structures.- Motif Construction from High–Throughput SELEX Data.- Rearrangement Phylogeny of Genomes in Contig Form.- Prediction of Contiguous Regions in the Amniote Ancestral Genome.- Pure Parsimony Xor Haplotyping.- A Decomposition of the Pure Parsimony Haplotyping Problem.- Exact Computation of Coalescent Likelihood under the Infinite Sites Model.- Imputation-Based Local Ancestry Inference in Admixed Populations.- Interpreting Population Sequencing Data.- Modeling and Visualizing Heterogeneity of Spatial Patterns of Protein-DNA Interaction from High-Density Chromatin Precipitation Mapping Data.- A Linear-Time Algorithm for Analyzing Array CGH Data Using Log Ratio Triangulation.- Mining of cis-Regulatory Motifs Associated with Tissue-Specific Alternative Splicing.- Analysis of Cis-Regulatory Motifs in Cassette Exons by Incorporating Exon Skipping Rates.- A Class of Evolution-Based Kernels for Protein Homology Analysis: A Generalization of the PAM Model.- Irreplaceable Amino Acids and Reduced Alphabets in Short-Term and Directed Protein Evolution.- A One-Class Classification Approach for Protein Sequences and Structures.- Prediction and Classification of Real and Pseudo MicroRNA Precursors via Data Fuzzification and Fuzzy Decision Trees.

Blurb

This book constitutes the refereed proceedings of the 5th International Symposium on Bioinformatics Research and Applications, ISBRA 2009, held in Fort Lauderdale, FL, USA, in May 2009.

The 26 revised full papers presented together four invited papers were carefully reviewed and selected from a total of 55  submissions. The papers cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.