The RECOMB Satellite Workshop on Comparative Genomics (RECOMB-CG) is a forum on all aspects and components of Comparative Genomics ranging from new quantitative discoveries about genome structures and processes to theorems on the complexity of computational problems inspired by genome comparison. Due to the interdiciplinary nature of the workshop, papers could be submitted merely for presentation at the workshop or for presentation at the workshop and publication in the proceedings. Speakers presenting papers of the former category are listed under Selected Presentations below. The workshop...

This book constitutes the thoroughly refereed post-proceedings of the RECOMB 2004 Satellite Workshop on Regulatory Genomics, RRG 2004, held in San Diego, CA, USA in March 2004. The 10 revised full papers presented were carefully reviewed and improved for inclusion in the book. The papers address a broad variety of aspects of regulatory genomics including classification, functional module detection, proteonomics, sampling, kernel methods, TF binding motifs, gene expression data analysis, regulatory network model learning, RNA regulatory sequence motifs, DNA regulatory sequence motifs,...

The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena.This first volume of the Transactions on Computational Systems Biology is made up of papers by members of the journal's Editorial Board to provide a representative and smart start-up to the new journal.

Cathal Seoighe, Beth Shapiro, Igor Sharakhov, Mike Steel, Jens Stoye, Glenn Tesler and Louxin Zhan. We would like to thank the ProgramCommittee members for their dedication and hard work.

We are pleased to present the proceedings of the 5th Workshop on Algorithms in Bioinformatics (WABI 2005) which took place in Mallorca, Spain, October 3 6, 2005. The WABI 2005 workshop was part of the ?ve ALGO 2005 conf- ence meetings, which, in addition to WABI, included ESA, WAOA, IWPEC, and ATMOS. WABI 2005 was sponsored by EATCS (the European Assoc- tion for Theoretical Computer Science), the ISCB (the International Society for Computational Biology), the Universitat Polit ecnica de Catalunya, the U- versitat de les Illes Balears, and the Ministerio de Educaci on y Ciencia. See http:...

It gives me great pleasure to present the Special Issue of LNCS Transactions on Computational Systems Biology devoted to considerably extended versions of selected papers presented at the International Workshop on Bioinformatics Research and Applications (IWBRA 2005). The IWBRA workshop was a part of the International Conference on Computational Science (ICCS 2005) which took place in Emory University, Atlanta, Georgia, USA, May 22 24, 2005. See http: //www.cs.gsu.edu/pan/ iwbra.htm for more details. The 10 papers selected for the special issue cover a wide range of bioinformatics research....

The field of bioinformatics has two main objectives: the creation and maintenance of biological databases, and the discovery of knowledge from life sciences data in order to unravel the mysteries of biological function, leading to new drugs and therapies for human disease. Life sciences data come in the form of biological sequences, structures, pathways, or literature. One major aspect of discovering biological knowledge is to search, predict, or model specific patterns of a given dataset, which have some relevance to an important biological phenomenon or another dataset. To date, many...

In the last few decades, advances in molecular biology and in the research - frastructure in this ?eld has given rise to the omics revolution in molecular biology, alongwiththeexplosionofdatabases: fromgenomicstotranscriptomics, proteomics, interactomics, and metabolomics. However, the huge amount of b- logicalinformationavailablehasleftabottleneckindataprocessing: information over?ow has called for innovative techniques for their visualization, modelling, interpretationandanalysis.The manyresultsfromthe ?eldsofcomputerscience andengineeringhavethenmetwithbiology, leadingto new,...

It gives us great pleasure to present the proceedings of the 4th Workshop on Algorithms in Bioinformatics (WABI 2004) which took place in Bergen, Norway, September 17 21, 2004. The WABI 2004 workshop was part of a ?- conference meeting, which in addition to WABI, included ESA, WAOA, IWPEC, and ATMOS, hosted by the University of Bergen, Norway. See http: //www.ii.uib.no/algo2004/ for more details. TheWorkshoponAlgorithmsinBioinformaticscoversresearchonallaspects of algorithmic work in bioinformatics. The emphasis is on discrete algorithms that address important problems in molecular biology....

This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2005, held in Sao Leopoldo, Brazil in July 2005.

The 15 revised full papers and 10 revised extended abstracts presented together with 3 invited papers were carefully reviewed and selected from 55 submissions. The papers address a broad range of current topics in computational biology and bioinformatics.