Biochemical Protozoology As A Basis For Drug Design

ISBN-13: 9780748400003 / Angielski / Twarda / 1991 / 635 str.

Graham H. Coombs

Opis

This is a compilation of articles on protozoological biochemistry which reviews the subject area and offers information on current research. Included in the topics covered are energy metabolism of anaerobic parasitic protists, proteinases of African tryphanosomes, purine metabolism in parasitic protozoa and its relationship to chemotherapy, and nucleoside transport in malaria. New therapies, antiprotozoal drugs and new targets for these drugs are considered.

Spis treści

The current status of biochemical protozoology, Graham H.Coombs and Michael J.North; the biochemistry of malaria - an overview, Irwin W.Sherman; pneumcystis carinii - potential targets for chemotherapeutic attack, Winston E. Gutteridge; giardia cysts - their biochemistry and metabolism, Edward L.Jarroll; the biochemical activities and importance of the ciliate protozoa in the rumen ecosyste, Alan G.Williams; energy Metabolism Of Anaerobic Parasitic Protists, Miklos Muller; The Effects Of environmental factors on the metabolism of giardia and trichomonas, David Lloyd and Tim A.Paget; energy metabolism in giardia intestinalis, Philip J.Schofield and Michael R.Edwards; amino acid catabolism in anaerobic Protists, Barbar C.Lockwood And Graham H.Coombs; Intermediary Metabolism of leishmania, J.Joseph Blum; glycosomes, Fred R.Operdoes; mitochondrial metabolism of African trypanosomes, Julio F.Turrens; mitochondria of plasmodium, Mitchell Fry; proteinases of mammals - an overview, Robert W.Mason; proteinases of parasitic protozoa - an overview, Michael J.North; new approaches to molecular analysis of proteinases of parasitic protozoa, James H.McKerrow and Judy Sakanari; proteinases of trypanosoma cruzi, Juan Jose Cazzulo; proteinases of African trypanosomes, John D.Lonsdale-eccles; cysteine proteinases of leishmanias, Graham H.Coombs et al; the promastigote surface proteinase of leishmania, Robert Etges and Jacques Bouvier; proteinases of trichomonads and giardia, Michael J.North; the cysteine proteinase of entamoeba histolytica - cloning of the gene and its roel as a virulence factor, J.H.McKerrow et al; amoebapian, the major proteinase of pathogenic entamoeba histolytica, Henning Scholze; proteinases of malaria parasites, Philip J.Rosenthal; plasmodium proteinases during the erythrocytic phase of infection, Joseph Schrevel et al; proteinases of babesias, Peter W.Riddles and Robert L.Blakeley; glycosylated-hosphatidyliositols of the trypanosomatidae, Malcolm J.McConville; structural variations of the leishmanial lipophosphoglycan, Salvatore J.Turco; lipid biochemistry of trypanosomatids, penny A.Haughan and L.John Goad; lipids and lipid metabolism of trichomonads tritrichomonas foetus and trichomonas vaginalis, D.G.Lindmark et al; lipid composition of the membranes of malaria-infected erythrocytes and the role of drug-lipid interactions in the mechanism of action of chloroquine and other antimalarials, Raphael Zidovetzki and Irwin W.Sherman; adaptation of leishmanias to an acidic environment, Dan Zilberstein; glucose uptake mechanisms as potential targets for drugs against trypanosomatids, Benno H.Ter Kuile; transport and compartmentation in entamoeba histolytica, Tilly Bakker-Grunwald. Part Contents.