Bioactive Spin Labels

ISBN-13: 9783642487262 / Angielski / Miękka / 2012 / 636 str.

Renat I. Zhdanov

Opis

Bioactive Spin Labels focusses on nitroxyl radicals, their chemistry, biological activity and their application as paramagnetic contrast agents in biomedical research. New EPR techniques for in-vivo studies utilizing nitroxyl radical reagents are described. Recent results on stable nitroxyl radicals as anticancer, antishock, antiaggregant and antischemic drugs are summarized.

Spis treści

Spin-Labeled Medicines: Enzymes, Biomembranes and Possible Pharmaceuticals. An Overview.- Nitroxyl Radicals and Non-Radical Reactions of Free Radicals.- Triacetonamine in the Chemistry of Nitroxyl Radicals.- Catalysis of Redox Processes by Nitroxyl Radicals.- Biomembrane Reactions of Nitroxyl Radicals.- Relaxation Processes Involving Nitroxyl Radicals in Molecular Biology.- Investigations on Spin Exchange in Nitroxyls by the Method of Continuous Saturation of EPR Spectra.- Spin Exchange Components in Nitroxyl Biradicals EPR Spectra.- Investigation of Spin Labels and Probes by Millimeter Band EPR.- Analysis of Spin Label Slow Motions Based on Simulating 2-mm Band EPR Spectra.- Synthesis and Properties of Spin-Labeled Phospholipids.- Spin-Labeled Phospholipids for Protein-Lipid Interactions.- Spin-Labeled Organophosphorus Compounds.- Spin-Labeled Close Analogs of Sugars and Nucleosides.- Spin-Labeling Study of the Structure and Function of Leucine Aminopeptidae.- Photoaffinity Spin Labeling.- The Toxicity of Aminoxyl Radicals.- Nitroxyl Radicals for Cancer Chemotherapy.- Spin Labeling Study of Platelet Plasma Membrane and Nitroxyl Aggregation Inhibitors.- Anti-Ischemic Effect of 1-Hydroxy Derivatives of Nitroxyl Bioantioxidants.- Spin Probes for the Study of Intact and Cancer Cell Membranes.- Pharmacokinetics of Nitroxyl Radicals.- Computer-Assisted Evaluation of Nitroxyl Radical Effect on Biological Activity.- Aminoxyl Radicals as MRI Contrast Agents.- Aminoxyl Spin Labels in Clinical Analysis.- Applications of Spin-Label Techniques at High Pressures.

O autorze

Bioactive Spin Labels is a collection of contributions by leading experts on nitroxyl radicals and their application in biomedicine. These compounds are used as side specific contrast agents for in-vivo EPR techniques. Their potential as drugs is investigated. Bioactive Spin Labels is a must for researchers in bioorganic chemistry, pharmacology and biomedicine.