Bilayer Lipid Membranes. Structure and Mechanical Properties

ISBN-13: 9780792335511 / Angielski / Twarda / 1995 / 436 str.

Tibor Hianik; Victor Ivanovich Passechnik

Opis

In Bilayer Lipid Membranes. Structure and Mechanical Properties the authors use new methods of measurement, which they have themselves developed, to present an analysis of the relation between membrane structure and viscoelastic properties, in particular in the transversal direction. Hianik and Passechnik's approach is fundamentally different from the usual one, in that they analyze lipid bilayer dynamics during various modes of deformation, arriving at a new, three-layer' model that accounts for the great heterogeneity of biomembranes. The macroscopic parameters of membranes have been measured using a wide variety of methods, leading to a discussion of the correlations between the parameters. There is also an extensive discussion of the dynamic changes in mechanical properties of lipid bilayers in the course of conformational transition of integral proteins. During the conformational changes of proteins, the structure of a bilayer undergoes a transition, reaching a new, stable membrane state. The book is the first to present a comprehensive analysis of long-distance interaction in lipid bilayers and of molecular mechanisms of mechanoreception.
Audience: Scientists and graduate students working in biophysics, membranology, physiology, medicine, pharmacology, bioelectronics, electrochemistry, and colloid chemistry.

Spis treści

Introduction. 1. The Elasticity and Viscosity of Biological Membranes. 2. The Measurement of the Elastic Modulus E_BOTTOM of Lipid Bilayer Membranes in a Transversal Direction. 3. Methods to Measure the Viscoelasticity of Bilayer Lipid Membranes and Liposomes. 4. The Peculiarity of the Electrical Field in Membranes and an Evaluation of their Capacitance. 5. The Bilayer Lipid Membrane as a Viscoelastic Body. 6. The Application of the Phenomena of the Generation of Higher Current Harmonics to the Solution of Different Biophysical Tasks and a Comparison of Microscopic and Macroscopic Parameters of Lipid Bilayers. 7. The Mechanical Properties of Lipid Bilayer under Different Action. 8. The Mechanical and Thermodynamical Properties of Lipid Bilayer due to the Incorporation and Conformational Changes of Membrane Proteins. 9. The Distortion of the Structure of Lipid Bilayer around Membrane Proteins and the Problems of Long-Distance Interactions. 10. The Mechanics of Lipid Bilayers and the Problems of Mechanoreception. Epilogue. Bibliography. Index.