Autophagy in Health and Disease

ISBN-13: 9780123851017 / Angielski / Twarda / 2012 / 227 str.

Roberta A. Gottlieb

Opis

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information.

• Discusses current understanding of the roles of autophagy in health and disease
• Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes

Recenzje

"...provides pertinent coverage of the cardiovascular system, immune system, gastrointestinal tract, as well as conditions such as diabetes and ischemia...a valuable resource for researchers, graduate students, and professionals." --Anticancer Research, February 2015

Spis treści

1. Overview: Removal of Aggregates and Organelles
2. Machinery and Genetics of Autophagy
3. Autophagy in the Cardiovascular System
4. Autophagy in the Immune System
5. Autophagy in the GI Tract
6. Autophagy in the Endocrine System
7. Development
8. Diabetes and Metabolic Syndrome
9. Ischemia/Reperfusion
10. Drug Discovery
11. Measuring Autophagy in Vivo
12. Aging, Nutrition, and Lifestyle

O autorze

Dr. Gottlieb has been conducting NIH-funded cardiovascular research for the past 20 years. She has prior experience with The Scripps Research Institute (TSRI); SDSU where she became the first Director of the Donald P. Shiley BioScience Center, and currently as the Director of Molecular Cardiobiology at Cedars-Sinai Heart Institute.

The work in her lab has led to the discovery of the cardioprotective agents and the elucidation of their novel mechanism of action. Her expertise in cardioprotection and autophagy is recognized on a national and international level.

Dr. Gottlieb is also an entrepreneur, having started a biotechnology company called Radical Therapeutix, to develop drugs to mitigate the damage to the heart during myocardial infarction. Dr. Gottlieb received her B.S. and M.D. degrees from Johns Hopkins University.