Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development

ISBN-13: 9780470870877 / Angielski / Twarda / 2007 / 384 str.

Don E. Pivonka; John M. Chalmers; Peter R. Griffiths

Opis

Although vibrational spectroscopy is a critical technology within the pharmaceutical industry, currently the literature regarding its applications in the field is fragmented. At present there is no single volume that brings together the diverse aspects of vibrational spectroscopy at a level that will provide value to the dedicated spectroscopist as well as to the synthetic, development and medicinal based chemists, alike. This volume aims to present key themes, established and emerging, within current research as well as presenting detailed contributions on the instrumentation, methodology, data treatment, and applications associated within this area of research. It will provide a consolidated "road map" to the practice of this science within the industry.

Spis treści

Part One: Introduction

Introduction to Vibrational Spectroscopy

Peter R. Griffiths

Part Two: Drug Discovery

Sampling Techniques and Fiber–Optic Probes

John M. Chalmers and Peter R. Griffiths

Vibrational Spectroscopy in the Discovery Phase Component of Pharmaceutical Research

Don E. Pivonka

Applications of Vibrational Spectroscopy to Combinatorial Chemistry

Don E. Pivonka

Vibrational Spectroscopic Analysis for the Determination of Structure–Activity Relationships (SARs) in Molecular Binding

Don E. Pivonka and Isao Noda

Applications of Vibrational Optical Activity in the Pharmaceutical Industry

Laurence A. Nafie and Rina K. Dukor

Characterization and Optimization of Chemical Synthesis Using Real–Time Vibrational Spectroscopy

Fadi Homsi, Paul Barrett, Jian Wang and Roel Ferwerda

Part Three: Drug Development

Infrared and Raman Spectroscopy for Process Development

George Zhou, Robert Guenard and Zhihong Ge

The Analysis of Pharmaceutical Substances and Formulated Products by Vibrational Spectroscopy

Don Clark and Alexander Pysik

Raman Analysis of Pharmaceuticals

David E. Bugay, Jan–Olav Henck, Michael L. Longmire and Fiona C. Thorley

Vibrational Spectroscopy of Solid–State Forms – Introduction, Principles and Overview

Terry L. Threlfall and John M. Chalmers

Vibrational Spectroscopy of Solid–State Forms – Applications and Examples

David H. Igo and Pingyun Chen

Pharmaceutical Applications of Chemical Mapping and Imaging

Don Clark, Mark Henson, Fred LaPlant, Slobodan Sasic and Lin Zhang

Terahertz Spectroscopy for Pharmaceutical Applications

Mike Claybourn, Husheng Yang, Lubomir Gradinarsky, Jonas Johansson and Staffan Folestad

Part Four: Conclusions

History, Trends and Prognostications

Peter R. Griffiths, John M. Chalmers and Don E. Pivonka