Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development

ISBN-13: 9780443153938 / Miękka / 2024 / 350 str.

Spis treści

Introduction. Antimicrobial peptides: from the bench to the bedside Section 1. Computational approaches 1. Bioinformatic methods for the design of antimicrobial peptides 2. Fundamentals of molecular dynamics for antimicrobial peptides' discovery 3. Artificial intelligence for the discovery of antimicrobial peptides 4. Computational tools for handling large databases of biological relevance 5. Statistical analysis and data interpretation Section 2. Experimental approaches 6. Chemical synthesis of peptides: conventional and novel routes 7. Physicochemical and biochemical characterization 8. Non-rational approaches based on microbial surface display 9. Classical and emerging approximations for the screening of peptide libraries 10. Scaling-up of biological production processes 11. Downstream processing 12. Physicochemical and biochemical characterization Section 3. Translational studies 13. Biological characterization: in vitro and in vivo studies 14. Pre-clinical and clinical studies 15. Formulation and product design 16. Packaging, long-term stability, and usability 17. Quality control and assurance