Anti-tumor and Immunomodulatory Properties of Adsorbed Ascites Fluid

ISBN-13: 9783845420233 / Angielski / Miękka / 100 str.

Ashish S. Verma; Anchal Singh

Opis

Immunosuppression is one of the most common reasons for the failure of immune-system to control tumor progression. Circulating immune-complexes (CICs) are one of the major contributing factors to induce as well as to maintain immune-suppression in tumor bearing host. Removal of CICs can reduce the burden of immunosuppressive factors, which helps to achieve immunopotentiation and anti-tumor effect. Protein A (PA) of Staphylococcus aureus Cowan I (SAC), is well known to bind with CICs more efficiently compared to immunoglobulins. Therefore, PA of SAC is used to remove CICs from ascites fluid (cell free). Adsorbed ascites fluid (ad-ASF) was used to treat ascites tumor bearing animals. This therapeutic intervention showed to have potential for the treatment of ascites tumor bearers, at least at experimental levels. This treatment has shown potentiation of both humoral immune response as well as cell mediated immune response. This book will be useful for post-graduate and doctoral students of life-sciences as well as researchers actively engaged in anti-tumor and immune-modulatory properties of biological response modifiers.

O autorze

Ashish S. Verma, Ph.D.: Professor Biotechnology at Amity University Uttar Pradesh, NOIDA, India. Received national and international awards. Worked in USA. To his credit 2 books, 30 papers and numerous book chapters.Anchal Singh, Ph.D.: Faculty member, A.T. Still University, Kirksville, USA. Published 2 books, 15 papers and 10 book chapters.