Animal Models in Toxicology

ISBN-13: 9781466554283 / Angielski / Twarda / 2015 / 1168 str.

Shayne C. Gad

Opis

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals. "

Recenzje

"…should be in every toxicology laboratory that performs research involving animals. No other book … provides the same breadth and depth of information as found here…"
—Michele T. Pritchard, PhD, University of Kansas Medical Center in Doody’s Book Reviews

Spis treści

Introduction. The Mouse. The Rat. The Hamster. The Guinea Pig. Rabbit. The Ferret. The Dog. Primates. The Minipig. Alternative Species. Clinical Pathology of Laboratory Animals. Telemetry in Nonclinical Drug Safety Assessment Studies. Molecular Imaging Techniques in Laboratory Animals. Genetically Modified Animal Models. Model Selection and Scaling (Allometry). Susceptibility Factors. Laws, Regulations, and Guidelines for Animal Care and Use in Research. Necropsy and Gross Pathology. Immunology Laboratory Endpoints for Assessment of Immunomodulators in Preclinical Studies and Case Studies Using Anti-CD3 mAb in Cynomolgus Monkey