Angiotensin and the Heart

ISBN-13: 9783798509368 / Angielski / Miękka / 1993 / 224 str.

Gerd Heusch; H. Grobecker; B. E. Strauer

Opis

This volumes provides an overview of the most recent findings on the role of angiotensin and associated mediators in cardiovascular adaptation and disease, with a particular emphasis on the treatment of such diseases by ACE inhibitors.

Spis treści

Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart.- Myocardial Perfusion.- Angiotensin, ACE-inhibitors and endothelial control of vasomotor tone.- Local and neurohumoral control of coronary blood flow.- ACE-inhibitors in coronary artery disease?.- Myocardial Hypertrophy.- Molecular mechanisms of cardiac gene expression.- Myocardial perfusion dependent and independent mechanisms of regional myocardial dysfunction in hypertrophy.- ACE-inhibitors and coronary microcirculation.- Ventricular Remodelling.- Myocardial fibrosis: role of angiotensin II and aldosterone.- Ventricular remodeling after myocardial infarction. Experimental and clinical studies.- Infarct Size, Reperfusion, Restenosis.- “Cardioprotection” by ACE-inhibitors in acute myocardial ischemia and infarction?.- Effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury: an overview.- Angiotensin-converting enzyme inhibitor in a human model of restenosis.- Heart failure.- Pathophysiology of heart failure and the renin-angiotensin-system.- Angiotensin-converting enzyme inhibitors in the treatment of clinical heart failure.- Summary and Perspectives.- A. Basic aspects.- B. Clinical aspects.