An Introduction to Toxicogenomics

ISBN-13: 9780849313349 / Angielski / Twarda / 2003 / 356 str.

Thomas E. Kubic; Michael E. Burczynski

Opis

Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies.A lthough toxicogenomics promises fast, efficient techniques and information-rich data, much

Recenzje

"… Burczynski has carefully constructed this volume to encompass background information and basic science through to applications and future uses. … [This book] takes a complex, nascent science, reducing its complexity to details and discussions at the level of the … readership."
- Veterinary Pathology, 42:1, 2005

"…a great text that explains the concepts underlying this new field to readers who will use these approaches in future research. It provides a comprehensive overview of this new discipline by focusing on toxicology. It's a good and needed guide to get into toxicogenomics in the right productive and accurate way."

- in Vet Human Toxicology

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Spis treści

FUNDAMENTALS OF EXPRESSION PROFILING ANALYSIS
Preparation and Utilization of Microarrays, Sophie Wildsmith and Fiona Spence
Comparative Studies Using cDNA versus Oligonucleotide Arrays, Jiang Li and Jeffrey A. Johnson
Quality Control of Expression Profiling Data, Andrew Hill and Maryann Whitley
An Introduction to Cluster Analysis, Frederick Immermann and Youping Huang

EXPRESSION PROFILING AND TOXICOLOGY: THE ADVENT OF TOXICOGENOMICS
Transcriptional Profiling in Toxicology, Julia Scheel, Marie-Charlotte von Brevern, and Thorsten Storck

MODEL SYSTEMS IN TOXICOGENOMIC STUDIES
Microarrays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers, David Gerhold, Jian Xu, and Thomas Rushmore
Characterization of Hepatocytes and Their Use as a Model System in Toxicogenomics, Thomas K. Baker, Marnie A. Higgins, Mark. A. Carfagna, and Timothy P. Ryan

MECHANISTIC TOXICOGENOMICS
Molecular Signatures of Dioxin Toxicity, J. Kevin Kerzee, Craig R. Tomlinson, Jennifer L. Marlowe, and Alvaro Puga
Toxicogenomic Dissection of the Antioxidant Response, Jiang Li and Jeffrey A. Johnson
An Overview of Mechanistic Toxicogenomic Studies, Julia Scheel, Marie-Charlotte von Brevern, and Thorsten Storck

PREDICTIVE TOXICOGENOMICS
Gene Expression Profile Databases in Toxicity Testing, Robert T. Dunn II and Kyle L. Kolaja
Predictive Toxicogenomics, Mark W. Porter, Arthur L. Castle, Michael S. Orr, and Donna L. Mendrick
Unsupervised Hierarchical Clustering of Toxicants, Jeffrey F. Waring and Roger G. Ulrich
Toxicogenomic Analysis in Clinical Phamacogenomic Studies, Michael E. Burczynski

THE FUTURE OF TOXICOGENOMICS
The Future of Toxicogenomics, John C. Rockett

O autorze

Michael E. Burczynski