Aminoacyl-Trna Synthetases in Biology and Medicine

ISBN-13: 9789401787000 / Angielski / Twarda / 2014 / 350 str.

Sunghoon Kim

Opis

This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.

Spis treści

Catalysis.- Emergence and Evolution.- Architecture.- Protein-protein Interactions and Multicomponent Complexes.- Interactions with RNAs.- Secretion and Circulation.- Regulatory Roles.- Neural Diseases.- Cancer.- Immune Diseases.- Pathologic Implications of Mitochondrial tRNA Synthetases .- Infectious Diseases.- Reprogramming of Genetic Code.- Novel functions of tRNAs.- Perspectives for Systems and Synthetic Bio-Medicine.

O autorze

1983–1986 Researcher, Genetic Eng. Center, KAIST, Korea
1991–1994 Post-doc, MIT, USA
1993–1994 Senior Scientist, Cubist Pharmaceuticals, USA
1994-2001 Associate Professor, Sung Kyun Kwan University, Korea
2001-present Professor, College of Pharmacy, Graduate Program in Bioinformatics , Genetic Engineering, Cancer Biology, Seoul National Univ.
1998-present Director, Center for Medicinal Protein Network and Systems Biology, Seoul National University
2008- Director, Information Center of Bio-pharmacological Network
2008- Director, Integrated Bioscience and Biotechnology Institute

Blurb

1 Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases

John J. Perona, Ita Gruic-Sovulj

2 Emergence and Evolution

Tammy J. Bullwinkle, Michael Ibba

3 Architecture and Metamorphosis

Min Guo, Xiang-Lei Yang

4 Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases

Jong Hyun Kim, Jung Min Han, Sunghoon Kim

5 Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication

Sung Hwa Son, Min Chul Park, and Sunghoon Kim

6. Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases

Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox

7 Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications

Sagi Tshori, Ehud Razin, Hovav Nechushtan

8 Association of Aminoacyl-tRNA Synthetases with Cancer

Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim

9 Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases

Hagen Schwenzer, Joffrey Zoll, Catherine Florentz, Marie Sissler

10 Role of Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development

Varun Dewan, John Reader, Karin-Musier Forsyth

11 Flexizymes, Their Evolutionary History and Diverse Utilities

Toby Passioura, Hiroaki Suga