Alkaloids: A Treasury of Poisons and Medicines

ISBN-13: 9780124173026 / Angielski / Twarda / 2014 / 294 str.

Shinji Funayama

Opis

Alkaloids are a large group of structurally complex natural products displaying a wide range of biological activities. The purpose of Alkaloids: A Treasury of Poisons and Medicines is to classify, for the first time, the alkaloids isolated from the natural sources until now. The book classifies all of the alkaloids by their biosynthetic origins. Of interest to the organic chemistry and medicinal chemistry communities involved in drug discovery and development, this book describes many alkaloids isolated from the medicinal plants, including those used in Japanese Kampo medicine.

• Classifies and lists alkaloids from natural sources
• Occurrence and biosynthetic pathways of alkaloids
• Indicates key uses and bioactivity of alkaloids

Spis treści

1: Alkaloids Derived from Phenylalanine and Tyrosine2: Alkaloids Derived from Tryptophan3: Alkaloids Derived from Ornithine (Arginine)4: Alkaloids Derived from Lysine 5: Alkaloids Derived from Proline6: Alkaloids Derived from Glutamic Acid7: Alkaloids Derived from Histidine8: Alkaloids Derived from 2,3-Diaminopropionic Acid9: Alkaloids Derived from Anthranilic Acid10: Alkaloids Derived from Nicotinic Acid11: Alkaloids Derived from Nucleic Acids and Related Compounds12: Alkaloids Possessing the Porphine Skeleton13: Alkaloids Derived from a m-C7N Unit14: Alkaloids Derived from Terpenoids15: Alkaloids Derived from Polyketides

O autorze

Professor Shinji Funayama obtained his Ph.D. in natural product chemistry at Tohoku University (Sendai, Japan) in 1980. After three years as a postdoctoral fellow at the Department of Pharmacognosy and Pharmacology, College of Pharmacy, University of Illinois at Chicago (UIC) under the supervision of Professor Geoffrey A. Cordell, he joined the Kitasato Institute (Tokyo, Japan) as a senior researcher. After seven years, he joined as a Lecturer and was promoted to Assistant Professor at the Pharmaceutical Institute, Tohoku University. After six years in this position, he joined as an Associate Professor at Aomori University (Aomori, Japan). He was promoted to Professor there, and also served as a Guest Professor at Hirosaki University. After eight years, he became a Professor at Nihon Pharmaceutical University (Saitama, Japan) in 2003 and served as a Department Head for 10 years.

He is the author of about 150 research publications, book chapters, comprehensive reviews, and professional publications; is the author of 11 books, with five more in progress; and is the Associate Editor-in-Chief of the Pharmaceutical Biology (USA). He is a Councilor of the Japanese Society for History of Pharmacy. His interests include the chemistry and biosynthesis of alkaloids, the relationship of poisons and human beings, the Japanese ancient history of Poisons and Medicines, and also the use of vegetables as chemical reagents.

Professor Emeritus Geoffrey A. Cordell obtained his Ph.D. in synthetic natural product chemistry at the University of Manchester in 1970. After two years as a NATO postdoctoral fellow at the Department of Chemistry, M.I.T., he joined the College of Pharmacy, University of Illinois at Chicago (UIC). A Professor since 1980, he served as a Department Head for 12 years and as Interim Dean of the College of Pharmacy for almost three years, as well as holding several other senior academic and research administrative positions at the Department, College, and Campus levels. He was the Co-founder of the US - Thai Consortium for Pharmacy Education, which developed and trained faculty for six new schools of pharmacy in Thailand. He retired from the University of Illinois in 2007. Since 1983, he has served as President of Natural Products Inc., a consulting company.

He is the author of about 600 research publications, book chapters, comprehensive reviews and professional publications; is the author of two books, with three more in progress; the editor of 37 books, including 29 volumes in the series "The Alkaloids: Chemistry and Biology”; is Associate Editor-in-Chief of the Chinese Journal of Natural Medicines; and a member of the Editorial Advisory Board of 26 international scientific journals. He is a former President of the American Society of Pharmacognosy, and is also an Honorary Member.

In 1981, he was an Alexander von Humboldt Fellow at the University of Munich with Professor Hildebert Wagner. He is an elected Fellow of the Royal Chemical Society, the Linnean Society of London, the American Society of Pharmacognosy, and the American Association of Pharmaceutical Scientists. In addition to assisting international organizations and corporations in several countries around the world to develop their research and academic programs, he is an Honorary Professor at Sichuan University, Chengdu, China; and at Amity University, Noida, India. He is also a Visiting Professor at universities in Peru, Malaysia, and Brasil, and an International Collaborative Partner of the UTAR Global Research Network in Malaysia in the areas of biodiversity and cancer. In addition, he is a member of the International Advisory Board of several natural product research institutes. His interests include the chemistry and biosynthesis of alkaloids, the sustainability and quality control of medicinal agents, the remote detection of biologically active natural products, and the use of vegetables as chemical reagents.